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Faculty Listed by Departmental Affiliation 

 

Myostatin is a secreted protein that normally acts to limit muscle growth. This image shows the expression of myostatin mRNA in developing somites during embryongenesis. Se-Jin Lee lab.

 

 



BCMB Faculty in the Department of Biological Chemistry

  • Caterina, Michael
    Molecular and Cellular Mechanisms of Pain Sensation
  • Cole, Robert N.
    Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer
  • Coulombe , Pierre A.
    Structural and signaling roles of cytoskeletal assemblies; Epithelial biology in health and disease
  • Devreotes, Peter
    Genetic analysis of chemotaxis in eukaryotic cells
  • Fukunaga, Ryuya
    Mechanism and biology of small silencing RNAs
  • Goley, Erin
    Bacterial cell biology: cytoskeletal function during growth and division
  • Gould, Stephen
    Exosome biogenesis and retrovirus budding
  • Hart, Gerald
    Dynamic O-GlcNAcylation of nuclear and cytosolic proteins.
  • Huganir, Richard
    Regulation of Neurotransmitter Receptor Function and Synaptic Plasticity in the Brain
  • Inoue, Takanari
    Synthetic cell biology: total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
  • Margolis, Seth
    Molecular Mechanisms of Synapse Formation in Development and Disease
  • Meffert, Mollie K.
    The Regulation of Neuronal Gene Expression in Health and Disease
  • O'Connor, Tamara
    Molecular dissection of host-pathogen interactions and the evolution of virulence strategies in natural reservoirs
  • Pandey, Akhilesh
    Global analysis of signal transduction pathways using mass spectrometry; Bioinformatics, sequence databases and annotation
  • Pomerantz, Joel L.
    Functional specificity and design of signal transduction pathways
  • Raben, Daniel
    Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades
  • Reddy, Karen
    Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation
  • Watkins, Paul
    Fatty Acid Activation Enzymes
  • Wolfgang, Michael
    Neurometabolic regulation of behavior and physiology in obesity, diabetes and neurological disease.
  • Zachara, Natasha
    The role of nucleocytoplasmic glycosylation, O-GlcNAc, in cell survival and the celluar stress response.

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BCMB Faculty in the Department of Biophysics & Biophysical Chemistry
  • Amzel, L. Mario
    Structural enzymology of redox and phosphoryl-transfer enzymes: MICAL, VP14, PI3K, and Nudix hydrolases. Selected areas of structural thermodynamics.
  • Berger, James M.
    Structural and molecular mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure
  • Frueh, Dominique
    Structural and dynamic studies of active enzymatic systems by Nuclear Magnetic Resonance (NMR) - Mechanisms of domain communication in Non-ribosomal Peptide Synthetases.
  • Ha , Taekjip
    Single-Molecule Studies of Genomic Maintenance
  • Lau, Albert
    Characterization of receptor-ligand interactions and macromolecular conformational transitions using computational and crystallographic approaches.
  • Sohn, Jungsan (Jay)
    We are interested in understanding how biological stress-sensors are assembled, detect danger signals, and initiate stress-response.
  • Wade, Herschel
    Molecular basis of multi-ligand•receptor specificity, ligand-dependent transcriptional regulation and bacterial multidrug resistance.
  • Wolberger, Cynthia
    Structural and molecular mechanisms of ubiquitin signaling and chromatin modifications; regulation of transcription
  • Wu, Bin
    ​Single molecule imaging, RNA biology, and gene expression
  • Xiao, Jie
    Quantitative understanding of gene expression and cell division at the single molecule and single cell levels. Single molecule fluorescence microscopy, live cell imaging, fluorescent reporter development.

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BCMB Faculty in the Department of Cell Biology
  • Andrew, Deborah
    Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
  • Devreotes, Peter
    Genetic analysis of chemotaxis in eukaryotic cells
  • Espenshade, Peter
    Mechanisms of Molecular Sensing
  • Ewald, Andrew
    Cellular mechanisms and molecular regulation of epithelial morphogenesis during development and breast cancer
  • Iijima, Miho
    Lipid Signaling in Chemotaxis
  • Inoue, Takanari
    Synthetic cell biology: total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
  • Li, Rong
    Cellular Dynamics in space, time, and adaptation
  • Machamer, Carolyn
    Intracellular protein trafficking; Golgi complex structure/function; apoptosis; intracellular virus assembly; coronaviruses
  • Matunis, Erika
    Molecular genetics of germ line stem cell function.
  • Michaelis, Susan
    Yeast Molecular Genetics; Protein Trafficking; ABC Transporters; CaaX protein processing; Cell-Cell Signaling
  • Robinson, Douglas
    Cytokinesis and Cell Shape Control
  • Sesaki, Hiromi
    Molecular Mechanisms and Physiological Roles of Mitochondrial Fusion and Division
  • Watanabe, Shigeki
    Cellular and molecular characterizations of rapid changes during synaptic plasticity
  • Wilson, Katherine
    Nuclear envelope, lamins and nucleoskeleton; Emery-Dreifuss muscular dystrophy.

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BCMB Faculty in the Department of Molecular Biology & Genetics

  • Clements, Janice
    Molecular Pathogenesis and Latency of SIV & HIV
  • Corden, Jeffry
    Regulation of gene expression through the RNA polymerase II C-terminal domain (CTD)
  • Cormack, Brendan
    Fungal pathogenesis: the host-pathogen interaction for the yeast pathogen Candida glabrata
  • Desiderio, Stephen
    Mechanisms of Development in the Immune System
  • Feinberg, Andrew
    Epigenetics in development and disease
  • Green, Rachel
    Ribosomal RNA and the mechanism of translation
  • Greider, Carol
    Telomeres and telomerase in chromosome maintenance and stability
  • Holland, Andrew
    Molecular mechanisms underlying accurate chromosome segregation and centrosome duplication
  • Kolodkin, Alex
    Molecular Mechanisms of Growth Cone Guidance
  • Lee, Se-Jin
    Regulation of mammalian development and adult tissue homeostasis by growth and differentiation factors
  • Nathans, Jeremy
    Molecular mechanisms of visual system development, function, and disease
  • Reed, Randall
    Molecular mechanisms of signal transduction and neurogenesis in the olfactory system
  • Regot, Sergi
    Signaling Network Dynamics at Single Cell Level - (Joining the Faculty September 2015)
  • Seydoux, Geraldine
    Molecular Genetics of Embryonic Polarity and Germ Cell Development
  • Siliciano, Robert
    Host-virus interaction in HIV infection
  • Soloski, Mark
    Innate and Adaptive Immune Recognition Events during Infection.
  • Urban, Sin
    Biochemistry, cell and chemical biology of intra-membrane proteases in cell signaling and microbial pathogenesis
  • Wheelan, Sarah
    Computational Biology, Genomics, and Sequence Alignment
  • Zack, Donald
    Molecular approaches to the study of retinal development and function

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BCMB Faculty in the Department of Neuroscience

  • Blackshaw, Seth
    Molecular basis of neuronal and glial cell fate specification and survival
  • Bosmans, Frank
    Molecular organization and pharmacological properties of the voltage-gated sodium channel signaling complex
  • Brown, Solange
    Our laboratory is focused on the function of the cerebral cortex which underlies our ability to interact with our environment through sensory perception and voluntary movement
  • Caterina, Michael
    Molecular and Cellular Mechanisms of Pain Sensation
  • Doetzlhofer, Angelika
    Cell specification and differentiation in the mammalian auditory system
  • Dong, Xinzhong
    Molecular and Genetic Studies of Pain-sensing Neurons
  • Goff, Loyal
    Long non-coding RNAs in neural cell fate decisions
  • Huganir, Richard
    Regulation of Neurotransmitter Receptor Function and Synaptic Plasticity in the Brain
  • Kolodkin, Alex
    Molecular Mechanisms of Growth Cone Guidance
  • Margolis, Seth
    Molecular Mechanisms of Synapse Formation in Development and Disease
  • Meffert, Mollie K.
    The Regulation of Neuronal Gene Expression in Health and Disease
  • Ming, Guo-Li
    Molecular and cellular mechanisms underlying neural development and neurodevelopmental psychiatric diseases
  • Pevsner, Jonathan
    Molecular basis of neurological disorders
  • Potter, Christopher J.
    Neuronal Circuits Required for Drosophila Olfaction
  • Qiu, Zhaozhu
    Mechanisms of Osmotic Regulation in Physiology and Disease
  • Schnaar, Ronald
    Molecular basis of cell-cell interactions in the nervous and immune systems; glycobiology
  • Snyder, Solomon H.
    Neurotransmitters, Second Messengers and Drug Action in the Nervous System
  • Sockanathan, Shanthini
    Cellular differentiation and degeneration in the nervous system
  • Song, Hongjun
    Neurogenesis and neuro-epigenetics
  • Worley, Paul
    Molecular mechanism of neuronal plasticity
  • Yau, King-Wai
    Visual and Olfactory Sensory Transductions
 
 

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BCMB Faculty in the Department of Pharmacology

  • Ambinder, Richard F.
    Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment
  • Barrow, James C.
    Drug discovery for disorders of neurodevelopment.
  • Bumpus, Namandje' N.
    Drug Metabolism and preclinical drug development; small molecule mass spectrometry for metabolite quantitation and identification; antiviral drug-induced toxicity; modulation of cellular signaling pathways by reactive metabolites.
  • Carr, Greg
    Preclinical models of neurological and psychiatric disorders
  • Cole, Philip
    Chemical approaches to the study of signal transduction, gene expression, and circadian rhythm.
  • Gibson, D. Wade
    Herpes virus proteins: synthesis, structure, and function during replication.
  • Hardwick, J. Marie
    Molecular mechanisms of programmed cell death.
  • Liu, Jun
    Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction, angiogenesis and cell proliferation
  • Meyers, Caren L.
    Organic and medicinal chemistry, chemical biology: drug delivery mechanisms in bacteria; development of antibiotic prodrug strategies; study of bacterial isoprenoid biosynthesis; combinatorial biosynthesis; development of potential therapeutic agents
  • Robinson, Douglas
    Cytokinesis and Cell Shape Control
  • Schnaar, Ronald
    Molecular basis of cell-cell interactions in the nervous and immune systems; glycobiology
  • Shapiro, Theresa A.
    Clinical pharmacology; molecular mechanisms of antiparasitic drug action; effects of topoisomerase inhibitors on DNA of trypanosomes; structure-activity of synthetic antimalarial trioxanes.
  • Taverna, Sean
    Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
  • Zhu, Heng
    Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics

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BCMB Faculty in the Department of Physiology

  • Bosmans, Frank
    Molecular organization and pharmacological properties of the voltage-gated sodium channel signaling complex
  • Claypool, Steven
    Mitochondrial lipid metabolism and the contribution of phospholipids in mitochondrial function and dysfunction.
  • Dawson, Valina
    Neuronal cell death; Parkinson's disease; Neuronal stem cell development; Neuronal cell survival
  • Fu, Dax
    Zinc physiology with a focus on structure, function and regulation of zinc transporters.
  • Guggino, William
    Structure/function studies of Cl- and water channels.
  • Kralli, Anastasia
    Regulatory pathways that control adaptive metabolic responses in adipose and skeletal muscle tissues
  • Lutsenko, Svetlana
    Copper homeostasis: mechanism of transport, protein and metabolic networks, integrative approches to human disease
  • Pluznick, Jennifer
    Renal physiology; the role of sensory receptors in regulating renal function; identifying renal olfactory receptor ligands and relating them to whole-animal physiology.
  • Qiu, Zhaozhu
    Mechanisms of Osmotic Regulation in Physiology and Disease
  • Raben, Daniel
    Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades
  • Rao, Rajini
    Discovery and molecular mechanisms of novel ion transporters.
  • Reeves, Roger
    Molecular genetic basis of Down syndrome; genomics; multiple organ dysfunction syndrome
  • Wong, Guang William
    Mechanisms governing metabolic homeostasis; function of adipose-and skeletal muscle-derived hormones; mechanisms of insulin resistance and type 2 Diabetes

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