Ambinder, Richard F.
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment
Amzel, L. Mario
Structural enzymology of redox and phosphoryl-transfer enzymes: MICAL, VP14, PI3K, and Nudix hydrolases. Selected areas of structural thermodynamics.
Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
Barrow, James C.
Drug discovery for disorders of neurodevelopment.
Berger, James M.
Structural and molecular mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure
Control of Neuronal and Glial Specification and Function
Molecular organization and pharmacological properties of the voltage-gated sodium channel signaling complex
Our laboratory is focused on the function of the cerebral cortex which underlies our ability to interact with our environment through sensory perception and voluntary movement.
Bumpus, Namandje' N.
Role of drug metabolism in non-nucleoside reverse transcriptase inhibitor-mediated toxicity.
Engineering stem cell fate
Preclinical models of neurological and psychiatric disorders
TRP channel function in thermosensation, pain, and inflammation
Mitochondrial Phospholipid Metabolism in Health and Disease.
Molecular Pathogenesis and Latency of SIV & HIV
Chemical approaches to the study of signal transduction, gene expression, and circadian rhythm.
Cole, Robert N.
Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer
RNA Polymerase II Phosphorylation and Transcription Regulation
Fungal pathogenesis: the host-pathogen interaction for the yeast pathogen Candida glabrata
Coulombe , Pierre A.
Structural and signaling roles of keratin cytoskeletal assemblies; Epithelial differentiation and homeostasis in health and disease; Cancer biology
Molecular mechanisms of neuronal death and survival; cell death and cell survival signaling pathways in models of stroke, and Parkinson's disease
Mechanisms of Development in the Immune System
Genetic analysis of chemotaxis eukaryotic cells
Cell specification and differentiation in the mammalian auditory system
Molecular and Genetic Studies of Pain-sensing Neurons
Mechanisms of Molecular Sensing
Cellular mechanisms and molecular regulation of epithelial morphogenesis during development and breast cancer
Epigenetics in development and disease
Structural and dynamic studies of active enzymatic systems by Nuclear Magnetic Resonance (NMR) - Mechanisms of domain communication in Non-ribosomal Peptide Synthetases.
Zinc physiology with a focus on structure, function and regulation of zinc transporters.
Mechanism and biology of small silencing RNAs
Gibson, D. Wade
Herpes virus proteins: synthesis, structure, and function during replication.
Long non-coding RNAs in neural cell fate decisions
Bacterial cell biology: cytoskeletal function during growth and division
Exosome biogenesis and retrovirus budding
Mechanisms of Ribosome Translation and Translational Control
Telomeres and telomerase in stem cell failure and cancer
Genetic disorders associated with defective fluid and electrolyte movement; ion channel and epithelial transport physiology.
Ha , Taekjip
Single-Molecule Studies of Genomic Maintenance
Hardwick, J. Marie
Molecular mechanisms of programmed cell death and its role in viral pathogenesis
Roles of cytoplasmic and nuclear glycosylation in transcription, oncogene function, neurodegenerative disease, and in diabetes
Molecular mechanisms underlying accurate chromosome segregation and centrosome duplication
Regulation of Neurotransmitter Receptors and Brain Function in Health and Disease
Lipid Signaling in Chemotaxis
Synthetic cell biology: total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
Molecular Mechanisms of Neuronal Growth Cone Guidance
Regulatory pathways that control adaptive metabolic responses in adipose and skeletal muscle tissues.
Characterization of receptor-ligand interactions and macromolecular conformational transitions using computational and crystallographic approaches.
Growth and differentiation factors, mammalian development
Cellular Dynamics in space, time, and adaptation
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction, angiogenesis and cell proliferation
Human copper homeostasis: mechanism of transport and compartmentalization of metal ions, protein and metabolic networks, inter-tissue communication in human diseases of copper misbalance.
Golgi complex structure/function; intracellular protein trafficking; intracellular virus assembly; coronaviruses; exocytosis of large cargo
Molecular Mechanisms of Synapse Formation in Development and Disease
Signals Regulating Stem Cell Self-renewal
Meffert, Mollie K.
The Regulation of Neuronal Gene Expression in Health and Disease
Meyers, Caren L.
Organic and medicinal chemistry, chemical biology: drug delivery; study of non-mammalian isoprenoid biosynthesis; development of potential therapeutic agents for cancer and infectious disease.
Progeria and lamin A processing; protein quality control mediated by the ubiquitin-proteasome system; mammalian and yeast cell biology.
Molecular and cellular mechanisms underlying neural development and neurodevelopmental psychiatric diseases
Molecular mechanisms of retinal development and disease; the role of Frizzled receptors in mammalian development.
Molecular dissection of host-pathogen interactions and the evolution of virulence strategies in natural reservoirs
Signal transduction; Mass spectrometry; Bioinformatics; Cancer biomarkers
Molecular basis of neurological disorders
Renal physiology; the role of sensory receptors in regulating renal function; localizing renal olfactory receptors and identifying their ligands in order to understand the role of each receptor in whole-animal physiology.
Pomerantz, Joel L.
Functional Specificity and Design of Signal Transduction Pathways
Potter, Christopher J.
Neuronal Circuits Required for Drosophila Olfaction
Mechanisms of Osmotic Regulation in Physiology and Disease
Structure, function, regulation and interfacial enzymology of lipid metabolizing enzymes involved in signal transduction cascades; biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades.
Ion tranpsorters in human health and disease. Calcium signaling in lactation and breast cancer. New roles for endosomal Na+/H+ exchangers in pH regulation, trafficking, and sodium homeostatis and their contribution to hypertension, autism and glioblastoma.
Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation
Molecular mechanisms of signal transduction and neurogenesis in the olfactory system
Characterize and treat the development and functional consequences of trisomy in Down Syndrome using model systems, human genetic studies, cell and molecular approaches.
Signaling Network Dynamics at Single Cell Level
Cytokinesis and Cell Shape Control
Molecular basis of cell-cell interactions in the nervous and immune systems; glycobiology
Molecular Mechanisms and Physiological Roles of Mitochondrial Fusion and Division
Molecular Genetics of Embryonic Polarity and Germ Cell Development
Shapiro, Theresa A.
Clinical pharmacology; molecular mechanisms of antiparasitic drug action; effects of topoisomerase inhibitors on DNA of trypanosomes; structure-activity of synthetic antimalarial trioxanes.
Host-virus interaction in HIV infection
Snyder, Solomon H.
Neurotransmitters, Second Messengers and Drug Action in the Nervous System
Cell fate specification in the central nervous system
Sohn, Jungsan (Jay)
We are interested in understanding how biological stress-sensors are assembled, detect danger signals, and initiate stress-response.
Structure and function of the genes and gene products of the mammalian major histocompatibility complex
Neurogenesis and Neuro-epigenetics
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
Biochemistry, cell and chemical biology of intra-membrane proteases in cell signaling and microbial pathogenesis
Molecular basis of multi-ligand•receptor specificity, ligand-dependent transcriptional regulation and bacterial multidrug resistance.
Cellular and molecular characterizations of rapid changes during synaptic plasticity
Fatty Acid Activation Enzymes
Computational Biology, Genomics, and Sequence Alignment
Nuclear envelope, lamins and nucleoskeleton; Emery-Dreifuss muscular dystrophy.
Mechanisms of ubiquitin signaling and transcriptional regulation
Cellular and organismal metabolism
Wong, Guang William
Mechanisms governing metabolic homeostasis; function of adipose- and skeletal muscle-derived hormones; mechanisms of insulin resistance and type 2 Diabetes
Molecular mechanism of neuronal plasticity
Single molecule imaging, RNA biology, and gene expression
My research group focuses on bacterial cell division, transcription and gene regulation. We combine sensitive, high resolution single-molecule methods with well established genetic and biochemical methods to address challenges in bacterial cell biology.
Cellular and Molecular Neuroscience
O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival.
Molecular approaches to the study of retinal development and function
Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics