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 Cancer Biology
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100 faculty found.

Ambinder, Richard F.(6;#Immunology;#7;#Virology)
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment

Amzel, L. Mario(15;#Enzymology;#8;#Structural Biology)
Structural enzymology of redox and phosphoryl-transfer enzymes: MICAL, VP14, PI3K, and Nudix hydrolases. Selected areas of structural thermodynamics.

Andrew, Deborah(1;#Developmental Biology;#2;#Genetics;#12;#Signal Transduction;#13;#Cancer Biology;#14;#Cell Adhesion;#35;#Cell Migration)
Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea

Barrow, James C.(3;#Channels/Transporters;#20;#Chemical Biology;#21;#Drug Design;#29;#Neurobiology)
Drug discovery for disorders of neurodevelopment.

Berger, James M.(20;#Chemical Biology;#9;#DNA Replication;#15;#Enzymology;#18;#Genome Structure/Chromatin;#8;#Structural Biology)
Structural and molecular mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure

Blackshaw, Seth(1;#Developmental Biology;#26;#Epigenetics;#18;#Genome Structure/Chromatin;#5;#Genomics/Proteomics;#28;#Metabolism;#29;#Neurobiology;#30;#Noncoding RNA)
Control of Neuronal and Glial Specification and Function

Bosmans, Frank(3;#Channels/Transporters;#27;#Membranes;#32;#Sensory Biology;#12;#Signal Transduction)
Molecular organization and pharmacological properties of the voltage-gated sodium channel signaling complex

Brown, Solange()
Our laboratory is focused on the function of the cerebral cortex which underlies our ability to interact with our environment through sensory perception and voluntary movement.

Bumpus, Namandje' N.(28;#Metabolism;#12;#Signal Transduction)
Role of drug metabolism in non-nucleoside reverse transcriptase inhibitor-mediated toxicity.

Cahan, Patrick(16;#Computational Biology;#1;#Developmental Biology;#5;#Genomics/Proteomics;#33;#Cell Differentiation)
Engineering stem cell fate

Carr, Greg()
Preclinical models of neurological and psychiatric disorders

Caterina, Michael(3;#Channels/Transporters;#4;#Neuronal Signaling;#12;#Signal Transduction;#13;#Cancer Biology;#14;#Cell Adhesion)
TRP channel function in thermosensation, pain, and inflammation

Claypool, Steven(27;#Membranes;#28;#Metabolism;#3;#Channels/Transporters)
Mitochondrial Phospholipid Metabolism in Health and Disease.

Clements, Janice(7;#Virology)
Molecular Pathogenesis and Latency of SIV & HIV

Cole, Philip(13;#Cancer Biology;#16;#Computational Biology;#21;#Drug Design;#15;#Enzymology;#26;#Epigenetics;#5;#Genomics/Proteomics;#12;#Signal Transduction;#8;#Structural Biology)
Chemical approaches to the study of signal transduction, gene expression, and circadian rhythm.

Cole, Robert N.(13;#Cancer Biology;#14;#Cell Adhesion)
Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer

Corden, Jeffry(2;#Genetics;#10;#Transcription/RNA Processing;#12;#Signal Transduction)
RNA Polymerase II Phosphorylation and Transcription Regulation

Cormack, Brendan(2;#Genetics;#5;#Genomics/Proteomics;#10;#Transcription/RNA Processing;#19;#Microbial Pathogenesis)
Fungal pathogenesis: the host-pathogen interaction for the yeast pathogen Candida glabrata

Coulombe , Pierre A. (25;#Cytoskeleton;#12;#Signal Transduction;#13;#Cancer Biology;#6;#Immunology;#33;#Cell Differentiation)
Structural and signaling roles of keratin cytoskeletal assemblies; Epithelial differentiation and homeostasis in health and disease; Cancer biology

Dawson, Valina(23;#Cell Death;#33;#Cell Differentiation;#16;#Computational Biology;#21;#Drug Design;#18;#Genome Structure/Chromatin;#5;#Genomics/Proteomics;#28;#Metabolism;#29;#Neurobiology;#12;#Signal Transduction;#8;#Structural Biology;#10;#Transcription/RNA Processing;#31;#Translation)
Molecular mechanisms of neuronal death and survival; cell death and cell survival signaling pathways in models of stroke, and Parkinson's disease

Desiderio, Stephen(1;#Developmental Biology;#2;#Genetics;#5;#Genomics/Proteomics;#6;#Immunology;#12;#Signal Transduction;#18;#Genome Structure/Chromatin)
Mechanisms of Development in the Immune System

Devreotes, Peter(14;#Cell Adhesion;#16;#Computational Biology;#1;#Developmental Biology;#2;#Genetics;#35;#Cell Migration)
Genetic analysis of chemotaxis eukaryotic cells

Doetzlhofer, Angelika(1;#Developmental Biology;#29;#Neurobiology;#30;#Noncoding RNA;#32;#Sensory Biology)
Cell specification and differentiation in the mammalian auditory system

Dong, Xinzhong(6;#Immunology;#29;#Neurobiology)
Molecular and Genetic Studies of Pain-sensing Neurons

Espenshade, Peter(13;#Cancer Biology;#2;#Genetics;#5;#Genomics/Proteomics;#27;#Membranes;#28;#Metabolism;#12;#Signal Transduction;#10;#Transcription/RNA Processing;#31;#Translation)
Mechanisms of Molecular Sensing

Ewald, Andrew(13;#Cancer Biology;#14;#Cell Adhesion;#24;#Cell Division;#1;#Developmental Biology;#2;#Genetics;#35;#Cell Migration)
Cellular mechanisms and molecular regulation of epithelial morphogenesis during development and breast cancer

Feinberg, Andrew(13;#Cancer Biology;#16;#Computational Biology;#1;#Developmental Biology;#26;#Epigenetics;#2;#Genetics;#18;#Genome Structure/Chromatin;#5;#Genomics/Proteomics;#6;#Immunology;#28;#Metabolism;#29;#Neurobiology;#30;#Noncoding RNA;#8;#Structural Biology;#10;#Transcription/RNA Processing;#12;#Signal Transduction)
Epigenetics in development and disease

Frueh, Dominique(20;#Chemical Biology;#16;#Computational Biology;#21;#Drug Design;#15;#Enzymology;#19;#Microbial Pathogenesis;#8;#Structural Biology)
Structural and dynamic studies of active enzymatic systems by Nuclear Magnetic Resonance (NMR) - Mechanisms of domain communication in Non-ribosomal Peptide Synthetases.

Fu, Dax(3;#Channels/Transporters;#8;#Structural Biology)
Zinc physiology with a focus on structure, function and regulation of zinc transporters.

Fukunaga, Ryuya(15;#Enzymology;#2;#Genetics;#30;#Noncoding RNA;#10;#Transcription/RNA Processing)
Mechanism and biology of small silencing RNAs

Gibson, D. Wade(7;#Virology;#8;#Structural Biology;#11;#Protein Targeting;#15;#Enzymology;#21;#Drug Design)
Herpes virus proteins: synthesis, structure, and function during replication.

Goff, Loyal()
Long non-coding RNAs in neural cell fate decisions

Goley, Erin(24;#Cell Division;#25;#Cytoskeleton)
Bacterial cell biology: cytoskeletal function during growth and division

Gould, Stephen(1;#Developmental Biology;#2;#Genetics;#7;#Virology;#11;#Protein Targeting)
Exosome biogenesis and retrovirus budding

Green, Rachel(10;#Transcription/RNA Processing;#15;#Enzymology;#30;#Noncoding RNA;#31;#Translation)
Mechanisms of Ribosome Translation and Translational Control

Greider, Carol(2;#Genetics;#9;#DNA Replication;#13;#Cancer Biology;#18;#Genome Structure/Chromatin)
Telomeres and telomerase in stem cell failure and cancer

Guggino, William(3;#Channels/Transporters;#5;#Genomics/Proteomics;#11;#Protein Targeting;#12;#Signal Transduction)
Genetic disorders associated with defective fluid and electrolyte movement; ion channel and epithelial transport physiology.

Ha , Taekjip(13;#Cancer Biology;#14;#Cell Adhesion)
Single-Molecule Studies of Genomic Maintenance

Hardwick, J. Marie(23;#Cell Death;#29;#Neurobiology;#13;#Cancer Biology;#27;#Membranes;#28;#Metabolism;#7;#Virology)
Molecular mechanisms of programmed cell death and its role in viral pathogenesis

Hart, Gerald(4;#Neuronal Signaling;#5;#Genomics/Proteomics;#10;#Transcription/RNA Processing;#12;#Signal Transduction;#13;#Cancer Biology;#22;#Glycobiology)
Roles of cytoplasmic and nuclear glycosylation in transcription, oncogene function, neurodegenerative disease, and in diabetes

Holland, Andrew(13;#Cancer Biology;#24;#Cell Division;#20;#Chemical Biology;#25;#Cytoskeleton;#18;#Genome Structure/Chromatin)
Molecular mechanisms underlying accurate chromosome segregation and centrosome duplication

Huganir, Richard(14;#Cell Adhesion;#3;#Channels/Transporters;#25;#Cytoskeleton;#1;#Developmental Biology;#21;#Drug Design;#15;#Enzymology;#26;#Epigenetics;#2;#Genetics;#5;#Genomics/Proteomics;#22;#Glycobiology;#27;#Membranes;#29;#Neurobiology;#30;#Noncoding RNA;#32;#Sensory Biology;#12;#Signal Transduction;#8;#Structural Biology)
Regulation of Neurotransmitter Receptors and Brain Function in Health and Disease

Iijima, Miho(13;#Cancer Biology;#24;#Cell Division;#25;#Cytoskeleton;#2;#Genetics;#27;#Membranes;#12;#Signal Transduction;#35;#Cell Migration)
Lipid Signaling in Chemotaxis

Inoue, Takanari(20;#Chemical Biology;#25;#Cytoskeleton;#27;#Membranes;#12;#Signal Transduction;#35;#Cell Migration)
Synthetic cell biology: total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation

Kolodkin, Alex(14;#Cell Adhesion;#25;#Cytoskeleton;#1;#Developmental Biology;#2;#Genetics;#29;#Neurobiology;#12;#Signal Transduction)
Molecular Mechanisms of Neuronal Growth Cone Guidance

Kralli, Anastasia()
Regulatory pathways that control adaptive metabolic responses in adipose and skeletal muscle tissues.

Lau, Albert(3;#Channels/Transporters;#16;#Computational Biology;#21;#Drug Design;#29;#Neurobiology;#12;#Signal Transduction;#8;#Structural Biology)
Characterization of receptor-ligand interactions and macromolecular conformational transitions using computational and crystallographic approaches.

Lee, Se-Jin(1;#Developmental Biology;#28;#Metabolism)
Growth and differentiation factors, mammalian development

Li, Rong(13;#Cancer Biology)
Cellular Dynamics in space, time, and adaptation

Liu, Jun(6;#Immunology;#8;#Structural Biology;#10;#Transcription/RNA Processing;#12;#Signal Transduction;#13;#Cancer Biology;#15;#Enzymology;#20;#Chemical Biology;#21;#Drug Design)
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction, angiogenesis and cell proliferation

Lutsenko, Svetlana()
Human copper homeostasis: mechanism of transport and compartmentalization of metal ions, protein and metabolic networks, inter-tissue communication in human diseases of copper misbalance.

Machamer, Carolyn(7;#Virology;#11;#Protein Targeting;#12;#Signal Transduction;#23;#Cell Death;#27;#Membranes)
Golgi complex structure/function; intracellular protein trafficking; intracellular virus assembly; coronaviruses; exocytosis of large cargo

Margolis, Seth(25;#Cytoskeleton;#1;#Developmental Biology;#29;#Neurobiology;#12;#Signal Transduction)
Molecular Mechanisms of Synapse Formation in Development and Disease

Matunis, Erika(13;#Cancer Biology;#14;#Cell Adhesion;#23;#Cell Death;#24;#Cell Division;#1;#Developmental Biology;#26;#Epigenetics;#2;#Genetics;#5;#Genomics/Proteomics;#12;#Signal Transduction)
Signals Regulating Stem Cell Self-renewal

Meffert, Mollie K.(13;#Cancer Biology;#5;#Genomics/Proteomics;#29;#Neurobiology;#30;#Noncoding RNA;#12;#Signal Transduction;#10;#Transcription/RNA Processing;#31;#Translation)
The Regulation of Neuronal Gene Expression in Health and Disease

Meyers, Caren L. (21;#Drug Design;#20;#Chemical Biology;#15;#Enzymology)
Organic and medicinal chemistry, chemical biology: drug delivery; study of non-mammalian isoprenoid biosynthesis; development of potential therapeutic agents for cancer and infectious disease.

Michaelis, Susan(3;#Channels/Transporters;#15;#Enzymology;#2;#Genetics;#18;#Genome Structure/Chromatin;#27;#Membranes)
Progeria and lamin A processing; protein quality control mediated by the ubiquitin-proteasome system; mammalian and yeast cell biology.

Ming, Guo-Li(13;#Cancer Biology)
Molecular and cellular mechanisms underlying neural development and neurodevelopmental psychiatric diseases

Nathans, Jeremy(1;#Developmental Biology;#2;#Genetics;#29;#Neurobiology;#32;#Sensory Biology;#13;#Cancer Biology)
Molecular mechanisms of retinal development and disease; the role of Frizzled receptors in mammalian development.

O'Connor, Tamara(13;#Cancer Biology;#2;#Genetics;#6;#Immunology;#19;#Microbial Pathogenesis;#12;#Signal Transduction)
Molecular dissection of host-pathogen interactions and the evolution of virulence strategies in natural reservoirs

Pandey, Akhilesh(2;#Genetics;#5;#Genomics/Proteomics;#6;#Immunology;#12;#Signal Transduction;#13;#Cancer Biology;#16;#Computational Biology)
Signal transduction; Mass spectrometry; Bioinformatics; Cancer biomarkers

Pevsner, Jonathan(5;#Genomics/Proteomics;#16;#Computational Biology;#2;#Genetics;#29;#Neurobiology;#12;#Signal Transduction;#26;#Epigenetics)
Molecular basis of neurological disorders

Pluznick, Jennifer(32;#Sensory Biology;#12;#Signal Transduction)
Renal physiology; the role of sensory receptors in regulating renal function; localizing renal olfactory receptors and identifying their ligands in order to understand the role of each receptor in whole-animal physiology.

Pomerantz, Joel L.(13;#Cancer Biology;#23;#Cell Death;#24;#Cell Division;#2;#Genetics;#18;#Genome Structure/Chromatin;#6;#Immunology;#19;#Microbial Pathogenesis;#12;#Signal Transduction;#10;#Transcription/RNA Processing;#7;#Virology;#31;#Translation)
Functional Specificity and Design of Signal Transduction Pathways

Potter, Christopher J.(1;#Developmental Biology;#29;#Neurobiology;#32;#Sensory Biology)
Neuronal Circuits Required for Drosophila Olfaction

Qiu, Zhaozhu(3;#Channels/Transporters;#29;#Neurobiology;#32;#Sensory Biology;#12;#Signal Transduction)
Mechanisms of Osmotic Regulation in Physiology and Disease

Raben, Daniel(12;#Signal Transduction;#15;#Enzymology;#27;#Membranes;#29;#Neurobiology)
Structure, function, regulation and interfacial enzymology of lipid metabolizing enzymes involved in signal transduction cascades; biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades.

Rao, Rajini(13;#Cancer Biology;#3;#Channels/Transporters;#27;#Membranes;#19;#Microbial Pathogenesis;#29;#Neurobiology;#12;#Signal Transduction)
Ion tranpsorters in human health and disease. Calcium signaling in lactation and breast cancer. New roles for endosomal Na+/H+ exchangers in pH regulation, trafficking, and sodium homeostatis and their contribution to hypertension, autism and glioblastoma.

Reddy, Karen(18;#Genome Structure/Chromatin;#5;#Genomics/Proteomics;#10;#Transcription/RNA Processing;#34;#Nuclear Structure)
Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation

Reed, Randall(1;#Developmental Biology;#2;#Genetics;#3;#Channels/Transporters;#4;#Neuronal Signaling;#10;#Transcription/RNA Processing;#32;#Sensory Biology)
Molecular mechanisms of signal transduction and neurogenesis in the olfactory system

Reeves, Roger(1;#Developmental Biology;#2;#Genetics;#31;#Translation)
Characterize and treat the development and functional consequences of trisomy in Down Syndrome using model systems, human genetic studies, cell and molecular approaches.

Regot, Sergi()
Signaling Network Dynamics at Single Cell Level

Robinson, Douglas(13;#Cancer Biology;#24;#Cell Division;#20;#Chemical Biology;#25;#Cytoskeleton;#16;#Computational Biology;#2;#Genetics)
Cytokinesis and Cell Shape Control

Schnaar, Ronald(4;#Neuronal Signaling;#12;#Signal Transduction;#14;#Cell Adhesion;#22;#Glycobiology;#27;#Membranes;#29;#Neurobiology)
Molecular basis of cell-cell interactions in the nervous and immune systems; glycobiology

Sesaki, Hiromi(1;#Developmental Biology;#2;#Genetics;#5;#Genomics/Proteomics;#6;#Immunology;#11;#Protein Targeting;#12;#Signal Transduction;#15;#Enzymology)
Molecular Mechanisms and Physiological Roles of Mitochondrial Fusion and Division

Seydoux, Geraldine()
Molecular Genetics of Embryonic Polarity and Germ Cell Development

Shapiro, Theresa A.(20;#Chemical Biology;#9;#DNA Replication;#21;#Drug Design;#18;#Genome Structure/Chromatin;#28;#Metabolism)
Clinical pharmacology; molecular mechanisms of antiparasitic drug action; effects of topoisomerase inhibitors on DNA of trypanosomes; structure-activity of synthetic antimalarial trioxanes.

Siliciano, Robert(6;#Immunology;#7;#Virology;#19;#Microbial Pathogenesis)
Host-virus interaction in HIV infection

Snyder, Solomon H.(4;#Neuronal Signaling;#12;#Signal Transduction)
Neurotransmitters, Second Messengers and Drug Action in the Nervous System

Sockanathan, Shanthini(1;#Developmental Biology;#29;#Neurobiology;#12;#Signal Transduction)
Cell fate specification in the central nervous system

Sohn, Jungsan (Jay)(20;#Chemical Biology;#15;#Enzymology;#6;#Immunology;#8;#Structural Biology)
We are interested in understanding how biological stress-sensors are assembled, detect danger signals, and initiate stress-response.

Soloski, Mark(6;#Immunology)
Structure and function of the genes and gene products of the mammalian major histocompatibility complex

Song, Hongjun()
Neurogenesis and Neuro-epigenetics

Taverna, Sean(26;#Epigenetics;#18;#Genome Structure/Chromatin)
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.

Urban, Sin(14;#Cell Adhesion;#20;#Chemical Biology;#3;#Channels/Transporters;#21;#Drug Design;#15;#Enzymology;#2;#Genetics;#27;#Membranes;#19;#Microbial Pathogenesis;#12;#Signal Transduction;#8;#Structural Biology)
Biochemistry, cell and chemical biology of intra-membrane proteases in cell signaling and microbial pathogenesis

Wade, Herschel(1;#Developmental Biology;#2;#Genetics;#6;#Immunology;#11;#Protein Targeting;#15;#Enzymology)
Molecular basis of multi-ligand•receptor specificity, ligand-dependent transcriptional regulation and bacterial multidrug resistance.

Watanabe, Shigeki ()
Cellular and molecular characterizations of rapid changes during synaptic plasticity

Watkins, Paul(13;#Cancer Biology;#15;#Enzymology;#28;#Metabolism;#29;#Neurobiology)
Fatty Acid Activation Enzymes

Wheelan, Sarah(16;#Computational Biology;#5;#Genomics/Proteomics)
Computational Biology, Genomics, and Sequence Alignment

Wilson, Katherine(1;#Developmental Biology;#9;#DNA Replication;#10;#Transcription/RNA Processing;#12;#Signal Transduction;#18;#Genome Structure/Chromatin;#34;#Nuclear Structure)
Nuclear envelope, lamins and nucleoskeleton; Emery-Dreifuss muscular dystrophy.

Wolberger, Cynthia(26;#Epigenetics;#18;#Genome Structure/Chromatin;#12;#Signal Transduction;#8;#Structural Biology;#10;#Transcription/RNA Processing)
Structural and molecular mechanisms of ubiquitin signaling and chromatin modifications; regulation of transcription

Wolfgang, Michael(20;#Chemical Biology;#15;#Enzymology;#2;#Genetics;#28;#Metabolism;#29;#Neurobiology)
Cellular and organismal metabolism

Wong, Guang William(28;#Metabolism;#12;#Signal Transduction)
Mechanisms governing metabolic homeostasis; function of adipose- and skeletal muscle-derived hormones; mechanisms of insulin resistance and type 2 Diabetes

Worley, Paul(4;#Neuronal Signaling;#11;#Protein Targeting;#12;#Signal Transduction)
Molecular mechanism of neuronal plasticity

Wu, Bin()
​Single molecule imaging, RNA biology, and gene expression

Xiao, Jie(24;#Cell Division;#25;#Cytoskeleton;#18;#Genome Structure/Chromatin;#5;#Genomics/Proteomics;#10;#Transcription/RNA Processing)
My research group focuses on bacterial cell division, transcription and gene regulation. We combine sensitive, high resolution single-molecule methods with well established genetic and biochemical methods to address challenges in bacterial cell biology.

Yau, King-Wai(3;#Channels/Transporters;#27;#Membranes;#29;#Neurobiology;#32;#Sensory Biology;#12;#Signal Transduction)
Cellular and Molecular Neuroscience

Zachara, Natasha(5;#Genomics/Proteomics;#11;#Protein Targeting;#12;#Signal Transduction;#13;#Cancer Biology;#15;#Enzymology;#22;#Glycobiology)
O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival.

Zack, Donald()
Molecular approaches to the study of retinal development and function

Zhu, Heng(5;#Genomics/Proteomics;#30;#Noncoding RNA;#10;#Transcription/RNA Processing)
Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics

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