Faculty & Research
|School of Medicine Address||725 N. Wolfe Street|
Baltimore MD 21205
|Link to Lab Homepage|
Research Topic: Renal physiology; the role of sensory receptors in regulating renal function; localizing renal olfactory receptors and identifying their ligands in order to understand the role of each receptor in whole-animal physiology.
Our lab is interested in the role that chemosensation plays in regulating physiological processes, particularly in the kidney and the cardiovascular system. We have found that sensory receptors (olfactory receptors, taste receptors, and other G-protein coupled receptors) are expressed in the kidney and in blood vessels, and that individual receptors play functional roles in whole-animal physiology. We are currently working to identify the full complement of sensory receptors found in the kidney, and are working to understand the role that each receptor plays in whole-animal physiology by using a variety of in vitro (receptor localization, ligand screening) and in vivo (whole-animal physiology) techniques.
Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ. (2013)
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A. 2013 Feb 11. [Epub ahead of print]
Pluznick JL, Caplan MJ. (2012)
Novel sensory signaling systems in the kidney. Curr Opin Nephrol Hypertens. 2012 Jul;21(4):404-9. doi: 10.1097/MNH.0b013e328354a6bd. Review.
, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ. (2011) Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium. PLoS One. 2011;6(5):e19694. doi: 10.1371/journal.pone.0019694. Epub 2011 May 13.PubMed
, Zou DJ, Zhang X, Yan Q, Rodriguez-Gil DJ, Eisner C, Wells E, Greer CA, Wang T, Firestein S, Schnermann J, Caplan MJ. Functional Expression of the Olfactory Signaling System in the Kidney. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2059-64. Epub 2009 Jan 27.PubMed
Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ. Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet. 2008 Oct 15;17(20):3105-17.
Wang X, Pluznick JL, Settles DC, Sansom SC. Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells. AJP:Renal. 2007 Dec;293(6):F1768-76.
Pluznick JL, Sansom SC. BK channels in the kidney: role in K+ secretion and localization of molecular components. AJP:Renal. 2006 Sep; 291(3):F517-29.
Pluznick JL, Wei P, Grimm RP, Sansom SC. The BK-β1 subunit: Immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion. AJP:Renal. 2005 Apr; 288(4):F846-54.
Wang X, Pluznick JL, Wei P, Padanilam BJ, Sansom SC. TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells. AJP: Cell. 2004 Aug; 287(2):C357-64.