Director of Human Stem Cells and Education
|School of Medicine Address||733 N. Broadway|
Baltimore MD 21205
|Link to Lab Homepage|
Research Topic: Molecular and cellular mechanisms underlying neural development and neurodevelopmental psychiatric diseases
The research of my laboratory centers on understanding the molecular mechanisms underlying neuronal development during both embryonic stages and in the adult brain, with a particular focus on the signaling events involved in cell morphogenesis, cell migration, axon/dendritic development and synapse formation. Using multifaceted approaches, we are interesting in identifying basic mechanisms regulating neuronal development. We have been using a combination of state-of art approaches, including multiphoton confocal imaging, molecular biology, immunocytochemistry, electrophysiology and optogenetics to study neural development both in the developing brain and in the adult hippocampus, where robust endogenous neurogenesis continues throughout the life. I hope our research will lead to critical knowledge of neurogenesis to harness the endogenous regenerative capacity for enhancing brain function and repair.
Autism, schizophrenia and major depression are psychiatric disorders with a neural developmental origin. We are also interested in the functions and mechanisms of risk genes for these mental disorder in neuronal development. We have been using both mouse model system and patient derived pluripotent stem cell (iPSCs) model system, with the goal to identify novel phenotypes associated with genetic insults. I hope our studies will lead to a better understanding of mechanisms underlying mental disorders and our long-term goal is to develop novel strategies for prevention and treatment.
Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J.U., Weng, Y-l., Gao, F., Geschwind, D.H., Coppola, G., Ming, G-l.
, and Song, H. (2015). Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience Epub ahead of printPubMed
Wen, W., Nguyen, H.N.N., Guo, Z., Lalli, M.A., Wang, X., Su, Y., Kim, N-S., Yoon, K.J., Shin, J., Zhang, C., Makri, G., Nauen, D., Yu, H., Guzman, E., Chiang, C-H., Yoritomo, N., Kaibuchi, K., Zou, J., Christian, K.M., Cheng, L., Ross, C.A., Magolis, R.L., Chen, G., Kosik, K.S., Song, H-j., and Ming, G-l.
(2014). Synaptic dysregulation in a human iPSC model of major mental disorders. Nature 515, 414-8.PubMed
Christian, K.M., Song, H. and Ming, G-l.
(2014). Functions and dysfunctions of adult hippocampal neurogenesis. Annual Review of Neuroscience 8, 243-62.PubMed
Yoon, K.J., Nguyen, H.N., Ursini, G., Zhang, F., Kim, N-S., Wen, Z., Makri, G., Nauen, D., Shin, J.H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini S, M.Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J.E., Hyde, T.M., Krauss, G., Christian, K.M., Rapoport, J.L., Weinberger, D.R., Song, H-j., and Ming, G-l.
(2014). Modelling a risk factor for schizophrenia in iPSCs and mice reveals neural stem cell function associated with adherens junctions and polarity. Cell Stem Cell 15, 79-91PubMed
Shim, S.-S., Zheng, J.Q. and Ming, G-l.
(2013). A critical role for STIM1 in filopodial calcium entry and axon guidance. Molecular Brain, 6:51.PubMed
Song, J., Sun, J., Moss, J., Wen, Z., Sun, G.J., Hsu, D., Zhong, C., Davoudi, H., Christian, K.M., Toni, N.*, Ming, G.L.
*, Song, H*. (2013). Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature Neuroscience, 16, 1728-30.PubMed
Sun, G.J., Sailor, K.A., Mahmood, Q., Chavali, N., Christian, K.M., Song, H. and Ming, G-l.
(2013). Seamless reconstruction of intact adult-born neurons by serial end-block imaging reveals complex axonal guidance and development in the adult hippocampus. Journal of Neuroscience 33, 11400-11PubMed
Jang, M-H. , Kitabatake, Y., Kang, E., Jun, H., Pletnikov, M.V., Christian, K.M., Hen, R., Lucae, S., Binder, E.B.*, Song, H.*, and Ming, G-l
.* (2013). Secreted Frizzled-related Protein 3 (sFRP3) regulates antidepressant responses in mice and humans. Molecular Psychiatry 18, 957-8.PubMed
Song, J., Zhong, C., Bonaguidi, M.A., Sun, G.J., Hsu, D., Gu, Y., Meletis, K., Huang, Z.J., Ge, S., Enikolopov, G., Deisseroth, K., Luscher, B., Christian, K., Ming, G-l
.*, and Song, H.* (2012). Neuronal circuitry mechanism regulating adult quiescent neural stem cell fate decision. Nature 489:150-4PubMed
Kim, J.Y., Liu, C.Y., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E., Lu, B., Rujescu, D., St Clair, D., Christian, K., Callicott, J.H., Weinberger, D.R., Song, H., and Ming, G.L
. (2012). Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell 148, 1051-64.PubMed
Kang, E., Burdick, K.E., Kim, J.Y., Duan, X., Guo, J.U., Sailor, K.A., Jung, D.E., Ganesan, S., Choi, S., Pradhan, D., Lu, B., Avramopoulos, D., Christian, K., Malhotra, A.K., Song, H., and Ming, G.L
. (2012). Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron 72, 559-71.PubMed
McGurk, J.S., Shim, S., Kim, J.Y., Wen, Z., Song, H., and Ming, G.L
. (2011). Postsynaptic TRPC1 function contributes to BDNF-induced synaptic potentiation at the developing neuromuscular junction. Journal of Neuroscience 31, 14754-62.PubMed
Bonaguidi, M.A., Wheeler, M.A., Shapiro, J.S., Stadel, R.P., Sun, G.J., Ming, G.L.
*, and Song, H.* (2011). In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145, 1142-55PubMed
Chiang, C.H., Su, Y., Wen, Z., Yoritomo, N., Ross, C.A., Margolis, R.L., Song, H-j. and Ming, G-l.
(2011). Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Molecular Psychiatry 16, 358-60.PubMed
Kim, J.Y., Duan, X., Liu, C.Y., Guo, J.U., Jang, M.H., Pow-anpongkul, N., Kang, E., Song, H-j. and Ming, G-l.
(2009). DISC1 regulates new neurons development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63, 761-73.PubMed