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BCMBJHU SOM

Faculty & Research

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Greg Carr

Department Affiliation Primary: Pharmacology
RankAssistant Professor
Phone Numbers443-287-4073
Emailgcarr3@jhmi.edu
School of Medicine Address855 N. Wolfe Street
Rangos 373
Baltimore MD 212205
Link to Lab Homepage
Greg Carr

Research Topic: Preclinical models of neurological and psychiatric disorders

​Psychiatric disorders and related neurodevelopmental disorders result from the complex interaction of multiple genetic and environmental risk factors. Our laboratory uses rodent models to determine how these risk factors modulate neurobiology and behavior. We utilize neurochemical, electrophysiological, and behavioral assays to interrogate the neural systems thought to be impaired in neurodevelopmental disorders. Our ultimate goal is to use this knowledge to inform drug discovery efforts designed to increase and improve the treatment options available for central nervous system disorders. We also conduct research focused on developing novel behavioral assays with increased translational value for screening novel therapeutics.

Publications:

Carr, G.V., Chen, J., Yang, F., Ren, M., Yuan, P., Tian, Q., Bebensee, A., Zhang, G.Y., Du, J., Glineburg, P., Xun, R., Akhile, O., Akuma, D., Pickel, J., Barrow, J.C., Papaleo, F., Weinberger, D.R. KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. Mol Psychiatry 2016 Nov; 21(11): 1517-1526. 

Detrait, E.R., Carr, G.V., Weinberger, D.R., Lamberty, Y. Brain catechol-O-methyltransferase (COMT) inhibition by tolcapone counteracts recognition memory deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic mice. Behav Pharmacol. 2016 Aug;27(5):415-21. 

Papaleo, F., Yang, F., Paterson, C., Palumbo, S., Carr, G.V., Wang, Y., Floyd, K., Huang, W., Thomas, C.J., Chen, J., Weinberger, D.R., Law, A.J. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. J Neurosci. 2016 Apr 27;36(17):4859-75. 

Carr, G.V.*, Jenkins, K.A.*, Weinberger, D.R., Papaleo, F. Loss of dysbindin‐1 in mice impairs reward‐based operant learning by increasing impulsive and compulsive behavior. Behav Brain Res. 2013; 241: 173-184.  *These authors contributed equally to this work. 

Carr, G.V., Schechter, L.E., Lucki, I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists. Psychopharmacology 2011; 213 (2-3): 499-507. 

Carr, G.V., Lucki, I. The role of serotonin receptor subtypes in treating depression: A review of animal studies. Psychopharmacology 2011; 213 (2-3): 265-287. 

Carr, G.V., Bangasser, D.A., Bethea, T., Young, M., Valentino, R.J., Lucki, I. Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats. Neuropsychopharmacology 2010; 35 (3): 752-763.


Carr, G.V., Bangasser, D.A., Bethea, T., Young, M., Valentino, R.J., Lucki, I. Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats. Neuropsychopharmacology 2010; 35 (3): 752-763.

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