Neuroscience

Xinzhong Dong

Xinzhong Dong

My laboratory has taken a multidisciplinary approach to understand the cellular and molecular mechanisms of different types of somatosensations including pain and itch, which are initiated and mediated by primary sensory neurons in dorsal root ganglia (DRG). We identified a novel family of G protein-coupled receptors (GPCRs) in mice called Mrgprs. Many of these receptors are exclusively expressed in distinct subsets of small-diameter DRG neurons. Mrgprs provide the sensory biology community a great molecular tool to study various aspects of DRG sensory neuron function.

Angelika Doetzlhofer

Angelika Doetzlhofer

Auditory hair cells, located in the inner ear cochlea are critical for our ability to detect sound. In mammals, neural innervated hair cells come in two flavors: inner hair cells, which are our primary mechanoreceptor and relay sound information to the brain and the signal amplifying outer hair cells. Inner and outer hair cells are structurally and functionally supported by different types of glial like supporting cells with which they share a close lineage relationship.

Seth Blackshaw

Seth Blackshaw

The vertebrate central nervous system (CNS) is an amazingly complex structure composed of distinct subtypes of neurons and glia.  To identify the molecular mechanisms that regulate cell specification in the CNS, we use the mouse retina and hypothalamus, both of which arise from the ventral embryonic forebrain.  The relatively simple anatomy of the retina provides an excellent system to identify molecular mechanisms that regulate neuronal cell fate.  The hypothalamus, which is a central regulator of behaviors ranging from sleep to feeding to reproduction, offers an opportunity

Pages