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Building body parts – discovering the mechanisms by which organs achieve their unique architectures and physiological specializations during embryonic development
We study how epithelial tubular organs – which are essential to life in all multicellular organisms – form and specialize. Using the simple unbranched tubes of the Drosophila salivary gland and the beautifully branched tubular network of the Drosophila respiratory system, we have learned how organ precursor cells are specified and we have discovered highly conserved transcription factors that control major aspects of organ form and function. Using a combination of classical and modern genetics, fixed and live high-resolution imaging in combination with genome-wide approaches, we are now uncovering the details of how these transcription factors coordinate morphogenesis with cell type specialization in the developing embryo. We are also leveraging our findings about the Drosophila salivary gland to develop strategies to block transmission of insect borne diseases. For more details on the systems we study, see Chung et al., 2014 or Loganathan et al., 2016.
Wells M.B. and Andrew D.J. (2019) Anopheles salivary gland architecture shapes Plasmodium sporozoite availability for transmission. MBio. 10(4): e01238-19.
Johnson, D.M. and Andrew, D.J. (2019) Role of tbc1 in Drosophila embryonic salivary glands. BMC Mol Cell Biol. 20:19.
Wells, M.B., Villamor, J. and Andrew, D.J. (2017) Salivary gland maturation and duct formation in the African malaria mosquito Anopheles gambiae. Scientific Reports. 7:601. PMID: 28377572
Chung, S., Kim, S., and Andrew, D.J. (2017) Uncoupling apical constriction from tissue invagination. Elife e22235. PMID: 28263180 PMCID: PMC5338918
Hanlon, C.D. and Andrew, D.J. (2016) Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. Dev Biol 419: 273-284. PMID: 27618755 PMCID: PMC5237845
Loganathan, R., Cheng, Y.L., and Andrew, D.J. (2016) Development of the Drosophila Respiratory System. Book Chapter in “Organogenetic gene networks: Genetic control of Organ Function”. Ed. J. Castelli-Gair and P. Bovolenta. Springer. p151-212
Loganathan, R., Lee, J.S., Wells, M.B., Grevengoed, E., Slattery, M. and Andrew, D.J. (2016) Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol 409: 234-250. PMID: 26477561 PMCID: PMC4750396.
Cheng, Y.L. and Andrew, D.J. (2015). Extracellular Mipp1 activity confers migratory advantage to epithelial cells during collective migration. Cell Reports 13:2174-88. PMID: 26628373 PMCID: PMC4776642
Wells, M.B. and Andrew, D.J. (2015) Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi. Parasites and Vectors 8:617. PMID: 26627194 PMCID: PMC4667400
Hanlon, C.D. and Andrew, D.J. (2015) Outside-in signaling - a brief review of GPCR signaling with a focus on the Drosophila GPCR family. J Cell Sci 128: 3533-3542. PMID: 26345366 PMCID: PMC4610211
Andrew, D.J. and Yelon, D. (2015) Developmental mechanisms, patterning and organogenesisis. Curr Opin Genet Dev. Epub 2015 Jun 4.
Chung, S.-Y., Hanlon, C.D. and Andrew, D.J. (2014) Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize. Wiley Interdiscip Rev Dev Biol 3: 281-300.
Chung, S.-Y. and Andrew, D.J. (2014) Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation. Development 141:1950-60. PMID: 24718992
Fox, R.M., Vaishnavi, A., Maruyama, R., and Andrew, D.J. (2013) Organ-specific gene expression: the bHLH protein Sage provides tissue-specificity to Drosophila FoxA. Development 140: 2160-71. PMID: 23578928
Ismat, A., Cheshire, A. and Andrew, D.J. (2013) The secreted AdamTS-A metalloprotease is required for collective cell migration. Development 140: 1981-1993. PMID: 23578928
Chung, S.-Y., Chavez, C. and Andrew, D.J. (2011) Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Developmental Biology 360: 160-172. PMID: 21963537
Fox, R.M., Hanlon, C.D. and Andrew, D.J. (2010) The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Journal of Cell Biology 191: 479-492. PMID: 21041443
Chung, S.-Y., Vining, M.S., Bradley, P.L., Chan, C.-C., Wharton, K.A. and Andrew, D.J. (2009) Serrano (Sano) functions with the planar cell polarity genes to control tracheal tube length PLoS Genetics 5(11): e1000746. PMID: 19956736
Kerman, B.E., Cheshire, A.M., Myat, M.M., and Andrew, D.J. (2008) Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin. Developmental Biology 320: 278-288. PMID: 18585700
Abrams, E.W., Mihoulides, W.K. and Andrew, D.J. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4SG1 and PH4SG2. Development 133: 3517-3527. PMID: 16914497
Myat, M.M. and Andrew, D.J. (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111: 879-891. PMID: 12526813
Bradley, P.L. and Andrew, D.J. (2001) ribbon encodes a BTB-containing transcription factor required for directed cell migration. Development 128: 3001-3015. PMID: 11532922
Myat, M.M. and Andrew, D.J. (2000) FORK HEAD prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development 127: 4217-4226. PMID: 10976053
Myat, M.M. and Andrew, D.J. (2000) Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia. Development 127: 679-691. PMID: 10648227
Isaac, D.D. and Andrew, D.J. (1996) Tubulogenesis in Drosophila: A requirement for the trachealess gene product. Genes and Development 10: 103-117. PMID: 8557189