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G. William Wong
G. William Wong
Center for Metabolism and Obesity Research
855 N. Wolfe Street
Baltimore MD 21205
Metabolic Physiology of Secreted Hormones
Our lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are broadly interested in how secreted hormones control various aspects of sugar and fat metabolism. Our current efforts centered on addressing how fat and muscle-derived secretory proteins (adipokines and myokines), identified in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use genetic approaches (gain and loss-of-function mouse models), and cell model systems, to address the function of CTRP family of hormones in physiological and pathophysiological context
Little HC, Rodriguez S, Lei, X, Tan SY, Stewart AN, Sahagun A, Sarver DC, Wong GW (2019). Myonectin deletion promotes adipose fat storage and reduces liver steatosis. FASEB J. (in press)
Stewart AN, Tan SY, Clark DJ, Zhang H, Wong GW (2019). N-linked glycosylation dependent and independent mechanisms regulating CTRP12 cleavage, secretion, and stability. Biochemistry. 58:727-741
Little HC, Tan SY, Cali FM, Rodriguez S, Lei X, Wolfe A, Hug C, Wong GW (2018). Multiplex quantification identifies novel exercise-regulated myokine/cytokines in plasma and in oxidative and glycolytic skeletal muscle. Mol Cell Proteomics. 17:1546-1563
Lei X, Seldin MM, Little HC, Choy N, Klonisch T, Wong GW (2017) CTRP6 links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 292:14836-14850
Petersen PS, Lei X, Wolf RM, Rodriguez S, Tan SY, Little HC, Schweitzer MA, Magnuson TH, Steele KE, Wong GW (2017). CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress. Am J Physiol (Endo). 312:E309-E325
Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW (2016). Loss of CTRP1 disrupts glucose and lipid homeostasis. Am J Physiol (Endo). 311: E678 –E697.
Lei X, Rodriguez S, Petersen PS, Seldin MM, Bowman CE, Wolfgang MJ, Wong GW. (2016) Loss of CTRP5 improves insulin sensitivity and hepatic steatosis. Am J Physiol (Endo). 310:E1036-E1052 Wolf RM,
Wolf RM, Yang ZC, Lei X, Nyandjo M, Tan SY, Wong GW (2016). CTRP3 deficiency reduces liver size and alters IL-6 and TGF-β levels in obese mice. Am J Physiol (Endo). 310:E332-E345
Wei Z, Lei X, Pedersen PS, Aja S, Wong GW. (2014) Targeted deletion of C1q/TNF-related protein 9 (CTRP9) increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice. Am J Physiol (Endo). 306:E779-E790
Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, Wong GW. (2014) C1q/TNF-related protein-4 (CTRP4) is a unique secreted protein with two tandem C1q domain that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem. 289:4055-4069
Seldin MM, Lei X, Tan S, Stanson KP, Wei Z, Wong GW. (2013) Skeletal muscle-derived myonectin activates the mTOR pathway to suppress autophagy in liver. J Biol Chem. 288:36073-82
Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, Wong GW. (2013) CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunctions. Am J Physiol (Regul). 305:R522-533.
Peterson JM, Wei Z, Aja S, and Wong GW. (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol (GI). 305:G214-224
Wei Z, Seldin MM, Natarajan N, DjemalDC, Peterson JM, and Wong GW. (2013) C1q/TNF-related protein-11 (CTRP11), a novel adipose stromal-derived regulator of adipogenesis. J Biol Chem. 288:10214-10229.
Wei Z, Lei X, Seldin MM, and Wong GW. (2012) Endopeptidase cleavage generates a functionally distinct isoform of C1q/TNF-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 287:35804-35814.
Seldin MM, Peterson JM, Byerly MS, Wei Z and Wong GW. (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287:11968-11980.
Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, and Wong GW. (2012) CTRP12, a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem. 287:10301-10315.
Peterson JM, Aja S, Wei Z and Wong GW. (2012) CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition. J Biol Chem. 287:1576-1587.
Wei Z, Peterson JM, and Wong GW. (2011) Metabolic regulation by CTRP13: Activation of AMP-activated protein kinase and suppression of lipid-induced JNK signaling pathway. J Biol Chem. 286: 15652-15665.
Peterson JM, Wei Z, Wong GW. (2010) CTRP3, a novel adipokine that regulates hepatic glucose output. J Biol Chem. 285: 39691-39701.
Wong GW, Krawczyk SA, Kitidis C, Ge G, Hug C, Spooner E, Gimeno R, and Lodish HF. (2009) Identification and functional characterization of CTRP9, a novel secreted glycoprotein from adipose tissue, that reduces serum glucose in obese mice and forms heterotrimers with adiponectin. FASEB J. 23:241-58.
Wong GW, Krawczyk SA, Kitidis C, Gimeno R, Revett T, and Lodish HF. (2008) Molecular, biochemical, and functional characterization of C1q/TNF family members: adipose tissue-selective expression patterns, regulation by PPAR-γ agonist, Cys-mediated oligomerizations, combinatorial associations, and metabolic function. Biochemical J. 416:161-77.
Wong GW, Wang J, Hug C, Tsao T-S, and Lodish HF. (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A. 101:10302-10307.