Luis Garza, MD-PhD

Luis Garza, MD-PhD

Associate Professor
Primary Appointment: 
Department of Dermatology
Secondary Appointment: 
Department of Cell Biology
Office: 410-955-8662
Lab: 410-955-3298

Department of Dermatology
Johns Hopkins School of Medicine
Room 204
Koch CRB II
1551 Orlelans Street
Baltimore, MD  21287

Research topic: 

Stem Cells and Regeneration

What if you could grow a new heart or liver if your first one failed? Our lab is interested if organogenesis can happen again in adults. We use skin as our model system and try to ask basic questions about fundamental biology with translational impact in medicine so that we use in vitro cell culture models, mouse models, and also human interventional clinical trials to gain understanding. We are currently focused on two areas. In the first, we are curious how normal noncoding endogenous dsRNA becomes unmasked and sensed by anti-viral sensors in the context of early wounding to prevent differentiation, maintain stem cells and promote regeneration/hair follicle appendage organogenesis. In the second, we are curious—if we can’t grow a new limb in people yet—can we at least reprogram the skin at the stump site of an amputee to be palmoplantar skin?

Selected Publications: 

Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G. Bald scalp in Men with Androgenetic Alopecia retains hair follicle stem cells but lacks CD200-rich and CD-34 positive hair follicle progenitor cells. Journal of Clinical Investigation. 121(2):613-622 2011.

Christman AL, Selvin E, Margolis D, Lazarus GS, Garza LA Hemoglobin A1c Predicts Healing Rate in Diabetic Wounds. Journal of Investigative Dermatology. 2011 131(10):2121-7

Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, et al. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia. Sci Transl Med. 2012;4(126):126ra34.

Yang NB, Garza LA, Foote CE, Kang S, Meyerle JH. High prevalence of stump dermatoses 38 years or more after amputation. Arch Dermatol. 2012;148(11):1283

Nelson AM, Loy DE, Lawson JA, Katseff AS, Fitzgerald GA, Garza LA. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44. J Invest Dermatol. 2013;133(4):881-9. PMCID: PMC3593761.

Vandiver AR, Irizarry RA, Hansen KD, Garza LA, Runarsson A, Li X, et al. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol. 2015;16(1):80. doi: 10.1186/s13059-015-0644-y. PubMed PMID: 25886480.

Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell. 2015;17(2):139-51. Epub 2015/08/09. doi: 10.1016/j.stem.2015.07.008. PubMed PMID: 26253200; PubMed Central PMCID: PMCPMC4529957.

Nelson AM, Katseff AS, Ratliff TS, Garza LA. Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration. Exp Dermatol. 2015. Epub 2015/11/15. doi: 10.1111/exd.12896. PubMed PMID: 26566817.

Nelson AM, Katseff AS, Resnik SR, Ratliff TS, Zhu AS, Garza LA. Interleukin 6 null mice paradoxically display increased Stat3 activity and wound-induced hair neogenesis. J Invest Dermatol. 2016. Epub 2016/02/02. doi: 10.1016/j.jid.2015.12.043. PubMed PMID: 26829029.

Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi Oh S, Park A, Han S, Yang NB, Qi J, Taube JM, Kang S, Garza LA. To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease. Am J Pathol. 2016;186(5):1140-50. Epub 2016/04/24. doi: 10.1016/j.ajpath.2015.12.030. PubMed PMID: 27105735.

Zhu AS, Li A, Ratliff TS, Melsom M, Garza LA. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration. J Invest Dermatol. 2017;137(7):1562-8. Epub 2017/04/11. doi: 10.1016/j.jid.2017.03.023. PubMed PMID: 28392344; PubMed Central PMCID: PMCPMC5483387.