Thomas Schaffer

Thomas Schaffer

BS, The Pennsylvania State University
Alumni
Selected Publications:
Cook EK, Sell GL, Schaffer TB, Margolis SS., 2019, "The emergence of Ephexin5 as a therapeutic target in Alzheimer's disease." Expert Opin Ther Targets. 23(4):263-265. PubMed
Schaffer, TB., Smith, JE., Cook, EK., Phan, T. and Margolis, SS., 2018, “PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5,” Cell Rep. 25(9):2470-2483.e8. PMID: 30485813 PubMed
Schmidt, K., Ralle, M., Schaffer, T., Jayakanthan, S., Bari, B., Muchenditsi, A. and Lutsenko, S., 2018, “ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal DOPAMINE-β-HYDROXYLASE,” J Biol Chem. pii: jbc.RA118.004889. PMID: 30341172 PubMed
Ramachandran, KV., Fu, JM., Schaffer, TB., Na, CH., Delannoy, M. and Margolis, SS., 2018, “Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome,” Mol Cell. 71(1):169-177.e6. PMCID: PMC6070390 [Available on 2019-07-05] PubMed
Sell, GL., Schaffer, TB., and Margolis, SS., 2017 “Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice,” J Clin Invest. pii: 85504. PMCID: PMC5409082 PubMed
Chan, W., Schaffer, TB. and Pomerantz, JL., 2013, "A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival," Mol Cell Biol. 33(2):429-43. PMCID: PMC3554118 Pubmed
Beginning year: 
2011
Graduation year: 
2018
Position: 
Scientist, Biochemistry and Assay Development
Affiliation: 
Columbia Biosciences Corporation
Affiliation type: 
Biotech/Pharma
Position type: 
R&D