Recent Publications

2017

Gonzalez-Hurtado, E., Lee, J., Choi, J., Selen Alpergin, ES., Collins, SL., Horton, MR. and Wolfgang, MJ., 2017, “The Loss Of Macrophage Fatty Acid Oxidation Does Not Potentiate Systemic Metabolic Dysfunction," Am J Physiol Endocrinol Metab :ajpendo.00408.2016. PubMed
El-Diwany, R., Cohen, VJ., Mankowski, MC., Wasilewski, LN., Brady, JK., Snider, AE., Osburn, WO., Murrell, B., Ray, SC., Bailey, JR., 2017, “Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1,” PLoS Pathog. 13(2):e1006235. PubMed
Li, Z., Tseng, PY., Tiwari, V., Xu, Q., He, SQ., Wang, Y., Zheng, Q., Han, L., Wu, Z., Blobaum, AL., Cui, Y., Tiwari, V., Sun, S., Cheng, Y., Huang-Lionnet, JH., Geng, Y., Xiao, B., Peng, J., Hopkins, C., Raja, SN., Guan, Y. and Dong, X., 2017, “Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain,” Proc Natl Acad Sci U S A. pii: 201615255.PubMed
Bachas, S., Kohrs, B. and Wade, HV.,2017, "Unconventional coupling between ligand recognition and allosteric control in the multidrug resistance gene regulator, BmrR," ChemMedChem. PubMed​
Phua, SC., Chiba, S., Suzuki, M., Su, E., Roberson, EC., Pusapati, GV., Setou, M., Rohatgi, R., Reiter, JF., Ikegami, K. and Inoue, T., 2017, "Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision," Cell. 168(1-2):264-279.e15. PMID: 28086093​ PubMed
Levine, MS., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, DC., Lansdorp, PM., Cleveland, DW., Lambrechts, D., Foijer, F. and Holland, AJ., 2017, “Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals,” Dev Cell. pii: S1534-5807(16)30917-0. PMCID: PMC5296221 PubMed
Schiffhauer, ES. and Robinson, DN., 2017, “Mechanochemical Signaling Directs Cell-Shape Change,”  Biophys J. 112(2):207-214. Review. PMCID: PMC5266144 PubMed
Peng, YJ., Zhang, X., Gridina, A., Chupikova, I., McCormick, DL., Thomas, RJ., Scammell, TE., Kim, G., Vasavda, C., Nanduri, J., Kumar, GK., Semenza, GL., Snyder, SH. and Prabhakar, NR., 2017, “Complementary roles of gasotransmitters CO and H2S in sleep apnea,” Proc Natl Acad Sci U S A. pii: 201620717. PMCID: PMC5307452 PubMed
Kumar, P., Tan., Y. and Cahan, P., 2017, “Understanding development and stem cells using single cell-based analyses of gene expression,” Development. 144(1):17-32. PMID: 28049689 PubMed
Campbell, DP., Chrysostomou, E. and Doetzlhofer, A., 2016, “Canonical Notch signaling plays an instructive role in auditory supporting cell development,” Sci Rep. 6:19484. PMCID: PMC472625 PubMed
Prasad, TS., Mohanty, AK., Kumar, M., Sreenivasamurthy, SK., Dey, G., Nirujogi, RS., Pinto, SM., Madugundu, AK., Patil, AH., Advani, J., Manda, SS., Gupta, MK., Dwivedi, SB., Kelkar, DS., Hall, B., Jiang, X., Peery, A., Rajagopalan, P., Yelamanchi, SD., Solanki, HS., Raja, R., Sathe, GJ., Chavan, S., Verma, R., Patel, KM., Jain, AP., Syed, N., Datta, KK., Khan, AA., Dammalli, M., Jayaram, S., Radhakrishnan, A., Mitchell, CJ., Na, CH., Kumar, N., Sinnis, P., Sharakhov, IV., Wang, C., Gowda, H., Tu, Z., Kumar, A. and Pandey, A., 2016, “Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes,” Genome Res. 27(1):133-144. PMCID: PMC5204337 PubMed
Burr, R., Stewart, EV., Shao, W., Zhao, S., Hannibal-Bach, HK., Ejsing, CS. and Espenshade, PJ., 2016, “Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast,” J Biol Chem. 291(23):12171-83. PMCID: PMC4933267 PubMed
Lee, J., Choi, J., Aja, S., Scafidi, S. and Wolfgang, MJ., 2016, “Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality,” Cell Rep. 14(6):1308-16. PMCID: PMC4758873 PubMed
Smith, J., Calidas, D., Schmidt, H., Lu, T., Rasoloson, D. and Seydoux, G., 2016, “Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3,” Elife. 5. pii: e21337. PMCID:PMC5262379  PubMed
Chen, Z., Dempsey, DR., Thomas, SN., Hayward, D., Bolduc, DM. and Cole, PA., 2016, “Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation,” J. Biol Chem. 291(27):14160-9. PMCID: PMC4933174 PubMed

2016

Cox, PM. and Bumpus, NN., 2016, “Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6,” ChemMedChem. PMID: 27860311. PubMed​
Su, Z., Wang, F., Lee, JH., Stephens, KE., Papazyan, R., Voronina, E., Krautkramer, KA., Raman, A., Thorpe, JJ., Boersma, MD., Kuznetsov, VI., Miller, MD., Taverna, SD., Phillips, GN. Jr. and Denu, JM., 2016, “Reader domain specificity and lysine demethylase-4 family function,” Nat Commun. 7:13387. PMCID: PMC5114558.  ​PubMed
Tan, SY., Little, HC., Lei, X., Li, S., Rodriguez, S. and Wong, GW., 2016, “Partial deficiency of CTRP12 alters hepatic lipid metabolism,” Physiol Genomics. :physiolgenomics.00111.2016.​ PubMed
Coutinho, K. and Inoue, T. 2016, "Deconstructing and constructing innate immune functions using molecular sensors and actuators," Proc.SPIE 9871, Sensing and Analysis Technologies for Biomedical and Cognitive Applications 987102. doi:10.1117/12.2225185. Link 
Mori, H., Bhat, R., Bruni-Cardoso, A., Chen, EI., Jorgens, DM., Coutinho, K., Louie, K., Bowen, BB., Inman, JL., Tecca, V., Lee, SJ., Becker-Weimann, S., Northen, T., Seiki, M., Borowsky, AD., Auer, M. and Bissell, MJ., 2016," New insight into the role of MMP14 in metabolic balance," PeerJ 4:e2142. PMCID: PMC4950575   PubMed
Shamir, ER., Pappalardo, E., Jorgens, DM., Coutinho, K., Tsai, W., Aziz, K., Auer, M., Tran, PT. and Ewald, AJ., 2014, "Twist1-induced dissemination preserves epithelial identity and requires E-cadherin," Journal of Cell Biology.204(5), 839-856. PMCID: PMC3941052  PubMed
Schiffhauer, ES., Luo, T., Mohan, K., Srivastava, V., Qian, X., Griffis, ER., Iglesias, PA., Robinson, DN., 2016, “Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton,” Curr Biol. 26(11):1473-9. PMID: 27185555 PubMed​
Chen, Z., Dempsey, DR., Thomas, SN., Hayward, D., Bolduc, DM. and Cole, PA., 2016, “Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation,” J Biol Chem. (27):14160-9. PMID: 27226612 PubMed
Greenspan, LJ. and Matunis, EL., 2017, “Live Imaging of the Drosophila Testis Stem Cell Niche,” Methods Mol Biol. 1463:63-74. PMID: 27734347 PubMed
Sluch, VM., Davis, CH., Ranganathan, V., Kerr, JM., Krick, K., Martin, R., Berlinicke, CA., Marsh-Armstrong, N., Diamond, JS., Mao, HQ. and Zack, DJ., 2015, “Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line,” Sci Rep. 5:16595. PMID: 26563826 PubMed
Shen, Y., Stracquadanio, G., Wang, Y., Yang, K., Mitchell, LA., Xue, Y., Cai, Y., Chen, T., Dymond, JS., Kang, K., Gong, J., Zeng, X., Zhang, Y., Li, Y., Feng, Q., Xu, X., Wang, J., Wang, J., Yang, H., Boeke, JD. and Bader, JS., 2016, “SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes,” Genome Res. 26(1):36-49. PMID: 26566658 ​PubMed
Lambrus, BG., Daggubati, V., Uetake, Y., Scott, PM., Clutario, KM., Sluder, G. and Holland, AJ., 2016, “A USP28-53BP1-p53-p21 signaling axis arrestsgrowth after centrosome loss or prolonged mitosis,” J Cell Biol. 214(2):143-53. PMID: 27432896 PubMed
Shamir, ER., Coutinho, K., Georgess, D., Auer, M. and Ewald, AJ., 2016, "Twist1+ epithelial cells retain adhesive and proliferative capacity throughout dissemination," Biol Open. pii: bio.019703. PMID: 27402962 PubMed
Lam, WY., Becker, AM., Kennerly, KM., Wong, R., Curtis, JD., Llufrio, EM., McCommis, KS., Fahrmann, J., Pizzato, HA., Nunley, RM., Lee, J., Wolfgang, MJ., Patti, GJ., Finck, BN., Pearce, EL. and Bhattacharya, D., 2016, "Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells," Immunity. 45(1):60-73. PMID: 27396958 PubMed
Nomura, M., Liu, J., Rovira, II., Gonzalez-Hurtado, E., Lee, J., Wolfgang, MJ., Finkel, T., 2016, "Fatty acid oxidation in macrophage polarization," Nat Immunol.17(3):216-7. PMID: 26882249 PubMed
Wasilewski, LN., El-Diwany, R., Munshaw, S., Snider, AE., Brady, JK., Osburn, WO., Ray, SC. and Bailey, JR., 2016, "A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal Antibodies," J Virol. 90(7):3773-82. PMID: 26819308 PubMed
Ellison, D., Mugler, A., Brennan, MD., Lee, SH., Huebner, RJ., Shamir, ER., Woo, LA., Kim, J., Amar, P., Nemenman, I., Ewald, AJ. and Levchenko, A., 2016, "Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis," Proc Natl Acad Sci U S A. 113(6):E679-88. PMID: 26792522 PubMed​
Mills, EW., Wangen, J., Green, R. and Ingolia, NT., 2016, "Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets," Cell Rep. 17(1):1-10. PMID: 27681415 PubMed​
Hwang, J., Ribbens, D., Raychaudhuri, S., Cairns, L.Gu, H., Frost, A., Urban, S. and Espenshade, PJ., 2016, "A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP," EMBO J. pii: e201693923. PMID: 27655872 PubMed
Freed, D. and Pevsner, J., 2016, "The Contribution of Mosaic Variants to Autism Spectrum Disorder," PLoS Genet. 12(9):e1006245. doi: 10.1371/journal.pgen.1006245. PMID: 27632392 PubMed
Avin, BA.*, Umbricht, CB.* and  Zeiger, MA.*, 2016, "Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing," (Review), nt J Oncol. PMID: 27779655   *equal contribution  PubMed
Tu-Sekine, B., Goldschmidt, HL. and Raben, DM., 2016, "DGK-θ: Structure, Enzymology, and Physiological Roles," Front Cell Dev Biol. 4:101. PMCID:PMC5021689. PubMed
Walker-Sperling, VE., Pohlmeyer, CW., Tarwater, PM. and Blankson, JN., 2016, "The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication," EBioMedicine. 8:217-29. PMCID: PMC4919475. PubMed
Laskey, SB., Pohlmeyer, CW., Bruner, KM. and Siliciano, RF., 2016, "Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality," PLoS Pathog. 12(8):e1005689. PMCID:PMC4975415. Pubmed
Hanlon, CD. and Andrew, DJ., 2016, "Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development," Dev Biol. 419(2):273-284. PMCID: PMC5237845. PubMed
Pohlmeyer, CW., Walker-Sperling, VE., Blankson, JN., 2016, "What can we do to reduce the viral reservoir in HIV-1-infected individuals?,"Future Microbiol. 11:839-42. PMID: 27416850. PubMed
Cheung, KJ., Padmanaban, V., Silvestri, V., Schipper, K., Cohen, JD., Fairchild, AN., Gorin, MA., Verdone, JE., Pienta, KJ., Bader, JS. and Ewald, AJ., 2016, "Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters," Proc Natl Acad Sci U S A. 113(7):E854-63.Epub 2016 Feb 1. PMID: 26831077 PubMed
Rodriguez, S., Lei, X., Petersen, PS., Tan, SY., Little, HC., Wong, GW., 2016, "Loss of CTRP1 disrupts glucose and lipid homeostasis," Am J Physiol Endocrinol Metab. 23:ajpendo.00087.2016. PMID: 27555298 PubMed
Martin-Eauclaire, MF., Salvatierra, J., Bosmans, F. and Bougis, PE., 2016, "The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension," FEBS Lett. PMID: 27528512 PubMed
Huebner, RJ., Neumann, NM., Ewald, AJ., 2016, "Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration," Development. 143(6):983-93. PMID: 26839364 PubMed
Ma, Q., de Cuevas, M., Matunis, EL., "Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary," Development. 143(5):754-63. PMID: 26811385  PubMed
Moreno, A., Froehlig, JR., Bachas, S., Gunio, D., Alexander, T., Vanya, A. and Wade, H., 2016, "Solution Binding and Structural Analyses Reveal Potential Multidrug Resistance Functions for SAV2435 and CTR107 and Other GyrI-like Proteins," Biochemistry. 55(34):4850-63. 18. PMID: 27505298 PubMed
Ferrandino, G., Nicola, JP., Sánchez, YE., Echeverria, I., Liu, Y., Amzel, LM. and Carrasco, N., Na+ coordination at the Na2 site of the Na+/I- symporter. Proc Natl Acad Sci U S A. pii: 201607231. PMID: 27562170 PubMed
Yuan, G., Peng, YJ., Khan, SA., Nanduri, J., Singh, A., Vasavda, C., Semenza, GL., Kumar, GK., Snyder, SH. and Prabhakar, NR., 2016, "H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea," Sci Signal. 9(441):ra80. PMID: 27531649 PubMed
Laskey, SB., Pohlmeyer, CW., Bruner, KM. and Siliciano, RF., 2016, "Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality,"  PLoS Pathog. 12(8):e1005689. PMID: 27494508 PubMed

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