Recent Publications

2014

Hua, ZL., Chang, H., Wang, Y., Smallwood, PM. and Nathans, J., 2014, "Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance," Development. 141(20):3944-54. PMCID: PMC4197693 PubMed
Ren, Y., West-Foyle, H., Surcel, A., Miller, C. and Robinson, DN., 2014, "Genetic suppression of a phosphomimic myosin II identifies system-level factors that promote myosin II cleavage furrow accumulation," Mol Biol Cell. 25(25):4150-65.  PMCID: PMC4263456  PubMed
Salgado, M., Gandhi, S., Buckheit, RW., Berkenblit, GV. and Blankson, JN., 2014, "Evolution of an attenuated HIV-1 isolate in an elite suppressor," AIDS Res Hum Retroviruses. 30(3):284-8. Epub 2013 Nov 13. PubMed
Cox, PM. and Bumpus, NN., 2014, "Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz," ACS Med Chem Lett. 5(10):1156-1161. PMCID: PMC4191608 PubMed​
Levine, MS. and Holland, AJ., 2014, "Polo-like kinase 4 shapes up," Structure, 22(8):1071-3.  PubMed
Kalia, J., Milescu, M., Salvatierra, J., Wagner, J., Klint, JK., King, GF., Olivera, BM. and Bosmans, F., 2014, "From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function," J Mol Biol. 427(1):158-75, Review. PMCID: PMC4277912 PubMed
Lee, DA., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. and Blackshaw, S., 2014, "Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice," Front Neurosci. 8:157. PMCID: PMC4056383 PubMed
Bende, NS., Dziemborowicz, S., Mobli, M., Herzig, V., Gilchrist, J., Wagner, J., Nicholson, GM., King, GF. and Bosmans, F., 2014, "A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a," Nat Commun. 5:4350. PMCID: PMC4115291 PubMed
Stine, RR., Greenspan, LJ., Ramachandran, KV. and Matunis, EL., 2014, "Coordinate Regulation of Stem Cell Competition by Slit-Robo and JAK-STAT Signaling in the Drosophila Testis," PLoS Genet. 10(11):e1004713. PMCID: PMC4222695  PubMed
Cleveland, TE 4th., McCabe, JM. and Leahy, DJ., 2014, "Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs," Protein Expr Purif, 104C, 92-102. PMCID: PMC4380871 PubMed
Kavran, JM., McCabe, JM., Byrne, PO., Connacher, MK., Wang, Z., Ramek, A., Sarabipour, S., Shan, Y., Shaw, DE., Hristova, K., Cole, PA. and Leahy, DJ.*, 2014, "How IGF-1 activates its receptor," Elife. 3. PMCID: PMC4381924 PubMed 
Kelkar, DS., Provost, E., Chaerkady, R., Muthusamy, B., Manda, SS., Subbannayya, T., Selvan, LD., Wang, CH., Datta, KK., Woo, S., Dwivedi, SB., Renuse, S., Getnet, D., Huang, TC., Kim, MS.,, Pinto, SM., Mitchell, CJ., Madugundu, AK., Kumar, P., Sharma, J., Advani, J., Dey, G., Balakrishnan, L., Syed, N., Nanjappa, V., Subbannayya, Y., Goel, R., Keshava Prasad, TS., Bafna, V., Sirdeshmukh, R., Gowda, H., Wang, C., Leach, SD. and Pandey, A., 2014, "Annotation of the Zebrafish Genome through an Integrated Transcriptomic and Proteomic Analysis," Mol Cell Proteomics. 13(11):3184-98. PMCID: PMC4223501 PubMed
Qing, Y., Yin, F., Wang, W., Zheng, Y., Guo, P., Schozer, F., Deng, H., and Pan, D., 2014, "The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6," Elife, 3.  PMCID: PMC4118621   PubMed
Mehta, S., Aye-Han, NN., Ganesan, A., Oldach, L., Gorshkov, K. and Zhang, J., 2014, "Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin," Elife. 3:e03765. PMCID: PMC4141273 PubMed
Berk, JM., Simon, DN., Jenkins-Houk, CR., Westerbeck, JW., Grønning-Wang, LM., Carlson, CR. and Wilson, KL., 2014, "The molecular basis of emerin-emerin and emerin-BAF interactions," J Cell Sci. 127(Pt 18):3956-69. PMCID: PMC4163644 PubMed
Zhou, Y. and Nathans, J., 2014, "Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling," Dev Cell. 31(2):248-56. PMCID: PMC4223636  PubMed
Rodriguez, S., Ellis, JM. and Wolfgang, MJ., 2014, "Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle," BMC Biochem. 15:20.  PMCID: PMC4236586 ​PubMed​
Rattner, A., Wang, Y., Zhou, Y., Williams, J. and Nathans, JH., 2014, "The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling," Invest Ophthalmol Vis Sci. 55(12):8614-25. PMCID: PMC4280883  PubMed
Zhang, H., Zou, B., Du, F., Xu, K. and Li, M., 2014, "Reporting Sodium Channel Activity using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5," Mol Pharmacol.87(2):207-17  PMCID: PMC4293450 PubMed
Wang, J. T., Smith, J., Chen, B.-C., Schmidt, H., Rasoloson, D., Paix, A., Lambrus, BG., Calidas, D., Betzig, E., and Seydoux, G., 2014, "Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically-disordered proteins in C. elegans," eLife, 3: e04591. PMCID: PMC4296509 PubMed
Heydarian, M., Luperchio, TR., Cutler, J., Mitchell, CJ., Kim, M., Pandey, A., Sollner-Webb, B. and Reddy, K., 2014, "Prediction of Gene Activity in Early B Cell Development Based on an Integrative Multi-Omics Analysis," J Proteomics Bioinform. 7. pii: 1000302. PMCID: PMC4276347 PubMed
Ma, Q., Wawersik, M. and Matunis, EL., 2014, "The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche," Dev Cell, 31(4):474-86. PMCID: PMC4254588  PubMed​
Tu-Sekine, B., Goldschmidt, H. and Raben, DM., 2014, "Diacylglycerol, phosphatidic acid, and their metabolic enzymes in synaptic vesicle recycling," Adv Biol Regul, 57:147-52. PubMed
Lu, C., Ward, A., Bettridge, J., Liu, Y. and Desiderio, S., 2014, "An Autoregulatory Mechanism Imposes Allosteric Control on the V(D)J Recombinase by Histone H3 Methylation," Cell Rep.10(1):29-38 PMCID: PMC4308961 PubMed
McCabe, JM. and Leahy, DJ., 2014, "Smoothened Goes Molecular: New Pieces in the Hedgehog Signaling Puzzle." J Biol Chem, 6: 3500-7 PMCID: PMC4319017 PubMed​
Freed, D., Stevens, EL. and Pevsner, J., 2014, "Somatic mosaicism in the human genome," Genes (Basel). 5(4):1064-94. Review. PMCID: PMC4276927 PubMed
Salvatierra, J., Lee, DA., Zibetti, C., Duran-Moreno, M., Yoo, S., Newman, EA., Wang, H., Bedont, JL., de Melo, J., Miranda-Angulo, AL., Gil-Perotin, S., Garcia-Verdugo, JM. and Blackshaw, S., 2014, "The LIM Homeodomain Factor Lhx2 Is Required for Hypothalamic Tanycyte Specification and Differentiation," J Neurosci. 34(50):16809-20. PMCID: PMC4261103 PubMed​
Lee J, Ellis JM, Wolfgang MJ. Adipose Fatty Acid Oxidation Is Required for Thermogenesis and Potentiates Oxidative Stress-Induced Inflammation. Cell Rep. 2015 Jan 7. pii: S2211-1247(14)01052-3. doi: 10.1016/j.celrep.2014.12.023. [Epub ahead of print] PubMed​
Suarez, A., Ueno, T., Huebner, R., McCaffery, JM. and Inoue, T., 2014, "Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells," Sci Rep. 4:4693.   PubMed
Hua, ZL., Jeon, S., Caterina, MJ. and Nathans, J., 2014, "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system," Proc Natl Acad Sci U S A. 111(29):E3005-14.  PMCID: PMC4115534​ PubMed
Cross, BM., Breitwieser, GE., Reinhardt, TA. and Rao, R., 2014, "Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology," Am J Physiol Cell Physiol. 306(6):C515-26. PMCID: PMC3948975 PubMed​
Bruner, JK., Zou, B., Zhang, H., Zhang, Y., Schmidt, K. and Li, M., 2014, "Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel," Eur J Pharmacol. pii: S0014-2999(14)00463-4. PubMed
Wong, X., Luperchio, TR. and Reddy, KL., 2014, "NET gains and losses: the role of changing nuclear envelope proteomes in genome regulation," Curr Opin Cell Biol. 28C:105-120.  Review.​ PubMed
Colis, L., Peltonen, K., Sirajuddin, P., Liu, H., Sanders, S., Ernst, G., Barrow, JC. and Laiho, M., 2014, "DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response," Oncotarget, 5(12):4361-4369. PMCID: PMC4147329 PubMed
Davis, CH., Kim, KY., Bushong, EA., Mills, EA., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, NA., Nguyen, JV., Jin, Y., Ellisman, MH. and Marsh-Armstrong, N., 2014, "Transcellular degradation of axonal mitochondria," Proc Natl Acad Sci U S A. 111(26):9633-8.  PMCID: PMC4084443 PubMed
Guzzo, CM., Ringel, A., Cox, E., Uzoma, I., Zhu, H., Blackshaw, S., Wolberger, C. and Matunis, MJ., 2014, "Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198," PLoS One. 9(8):e105271. PMCID: PMC4136804​ PubMed
Kuang, Z., Cai, L., Zhang, X., Ji, H., Tu, BP. and Boeke, JD., 2014, "High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast," Nat Struct Mol Biol. 21(10):854-63  PMCID: PMC4190017 ​ PubMed
Papazyan, R., Voronina, E., Chapman, JR., Luperchio, TR., Gilbert, TM., Meier, E., Mackintosh, SG., Shabanowitz, J., Tackett, AJ., Reddy, KL., Coyne, RS., Hunt, DF., Liu, Y. and Taverna, SD., 2014, "Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis," Elife. 3:e02996. PMCID: PMC4141274 PubMed
Cieniewicz, AM., Moreland, L., Ringel, AE., Mackintosh, SG., Raman, A., Gilbert, TM., Wolberger, C., Tackett, AJ. and Taverna, SD., 2014, "The bromodomain of Gcn5 regulates site-specificity of lysine acetylation on histone H3," Mol Cell Proteomics,13(11):2896-910.  PMCID: PMC4223480 PubMed
Gilbert, TM., McDaniel, SL., Byrum, SD., Cades, JA., Dancy, BC., Wade, H., Tackett, AJ., Strahl, BD. and Taverna, SD., 2014, "An H3K36me3 binding PWWP protein targets the NuA3 acetyltransferase complex to coordinate transcriptional elongation at coding regions," Mol Cell Proteomics, 13(11):2883-95. PMCID: PMC4223479​ PubMed
Li, Y., Ma, Q., Cherry, CM. and Matunis, EL., 2014, "Steroid signaling promotes stem cell maintenance in the Drosophila testis," Dev Biol. 394(1):129-41.  PMCID: PMC4165524​ PubMed
Kim, YJ., Lim, H., Li, Z., Oh, Y., Kovlyagina, I., Choi, IY., Dong, X. and Lee, G., 2014, "Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor," Cell Stem Cell, 15(4):497-506 ​ PubMed
Debeljak, M., Freed, DN., Welch, JA., Haley, L., Beierl, K., Iglehart, BS., Pallavajjala, A., Gocke, CD., Leffell, MS., Lin, MT., Pevsner, J., Wheelan, SJ and Eshleman, JR., 2014, "Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection," J Mol Diagn. 16(5):495-503.      PubMed 
Colis, L., Ernst, G., Sanders, S., Liu, H., Sirajuddin, P., Peltonen, K., DePasquale, M., Barrow, JC. and Laiho, M., 2014, "Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors," J Med Chem 57(11):4950-61.​ PMCID: PMC4059246​ PubMed 
Prendergast, J., Umanah, GK., Yoo, SW., Lagerlöf, O., Motari, MG., Cole, RN., Huganir, RL., Dawson, TM., Dawson, VL. and Schnaar, RL., 2014, "Ganglioside regulation of AMPA receptor trafficking," J Neurosci. 34(39):13246-58. PMCID: PMC4172811  PubMed
Paix, A., Wang, Y., Smith, H., Lee, CY., Calidas, D., Lu, T., Smith, J., Schmidt, H., Krause, M. and Seydoux, G., 2014, "Scalable and Versatile Genome Editing Using Linear DNAs with Micro-homology to Cas9 Sites in Caenorhabditis elegans," Genetics, 198(4):1347-56.  PMCID: PMC4256755 PubMed
Li, Z., He, SQ., Xu, Q., Yang, F., Tiwari, V., Liu, Q., Tang, Z., Han, L., Chu, YX., Wang, Y., Hin, N., Tsukamoto, T., Slusher, B., Guan, X., Wei, F., Raja, SN., Dong, X. and Guan, Y., 2014, "Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice," Pain, 155(8):1613-21. PMCID: PMC4104261  PubMed
Huebner, RJ. and Ewald, AJ., 2014, "Cellular foundations of mammary tubulogenesis," Semin Cell Dev Biol, 31:124-31. Review.​ PMCID: PMC4116098 PubMed
Sluch, VM. and Zack, DJ. 2014, "Stem cells, retinal ganglion cells and glaucoma," Dev Ophthalmol. 53:111-21. PMCID: PMC4547935  PubMed
Kim, MS., Pinto, SM., Getnet, D., Nirujogi, RS., Manda, SS., Chaerkady, R., Madugundu, AK., Kelkar, DS., Isserlin, R., Jain, S., Thomas, JK., Muthusamy, B., Leal-Rojas, P., Kumar, P., Sahasrabuddhe, NA., Balakrishnan, L., Advani, J., George, B., Renuse, S., Selvan, LD., Patil, AH., Nanjappa, V., Radhakrishnan, A., Prasad, S., Subbannayya, T., Raju, R., Kumar, M., Sreenivasamurthy, SK., Marimuthu, A., Sathe, GJ., Chavan, S., Datta, KK., Subbannayya, Y., Sahu, A., Yelamanchi, SD., Jayaram, S., Rajagopalan, P., Sharma, J., Murthy, KR., Syed, N., Goel, R., Khan, AA., Ahmad, S., Dey, G., Mudgal, K., Chatterjee, A., Huang, TC., Zhong, J., Wu, X., Shaw, PG., Freed, D., Zahari, MS., Mukherjee, KK., Shankar, S., Mahadevan, A., Lam, H., Mitchell, CJ., Shankar, SK., Satishchandra, P., Schroeder, JT., Sirdeshmukh, R., Maitra, A., Leach, SD., Drake, CG., Halushka, MK., Prasad, TS., Hruban, RH., Kerr, CL., Bader, GD., Iacobuzio-Donahue, CA., Gowda, H. and Pandey, A., 2014, "A draft map of the human proteome, "Nature. 509(7502):575-81. PMCID: PMC4403737 PubMed

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