Netzahualcóyotl Arroyo Currás

Netzahualcóyotl Arroyo Currás

Assistant Professor
Primary Appointment: 
Pharmacology and Molecular Sciences

725 North Wolfe Street
316 Hunterian Building
Baltimore, MD 21205

Research topic: 

Pharmacokinetics, Biosensors, In-vivo sensing

The ability to monitor arbitrary molecules in situ in the body as we undergo normal daily routines could empower us to make educated decisions regarding our diet, fitness, medical treatments and overall health status. Our laboratory pursues this vision by developing biology-inspired electrochemical sensors that support real-time, continuous measurements of a wide range of physiologically-important molecules in vivo. Our research blends chemistry with engineering, biophysics and pharmacology to, for example, study factors involved in the recognition of small-molecule targets by nucleic acid- or peptide-based receptors, develop metabolism-responsive drug delivery approaches, and produce diagnostic platforms for personalized health care. We pursue these goals in an environment that nurtures creativity, inclusivity of ideas, and innovation.

Selected Publications: 

2020

• E-DNA scaffold sensors and the reagentless, single-step, measurement of HIV-diagnostic antibodies in human serum. Parolo, C.; Greenwood, A. S.; Ogden, N. E.; Kang, D.; Hawes, C.; Ortega, G.; Arroyo-Currás, N.; Plaxco, K. W.; Nature Microsyst. Nanoeng., 2020, DOI: 10.1038/s41378-019-0119-5

• Alkanethiol Monolayer End Groups Affect the Long-term Operational Stability and Signaling of Electrochemical, Aptamer-based Sensors in Biological Fluids. Shaver, A; Curtis, S.; Arroyo-Currás, N.; ACS Appl. Mater. Interfaces, 2020, DOI: 10.1021/acsami.9b22385

• From the Beaker to the Body: Translational Challenges for Electrochemical, Aptamer-Based Sensors. Arroyo-Currás, N.; Dauphin-Ducharme, P.; Scida, K.; Chavez, J.L.; Anal. Methods, 2020, DOI: 10.1039/D0AY00026D 2019

2019

• Approaches for the Electrochemical Interrogation of DNA-Based Sensors: A Critical Review. Pellitero, M. A.; Shaver, A.; Arroyo-Currás, N.; J. Electrochem. Soc., 2019, DOI: 10.1149/2.0292003JES

• Discharging Behavior of Confined Bipolar Electrodes: Coupled Electrokinetic and Electrochemical Dynamics. Eden, A.; Scida, K.; Arroyo-Currás, N.; Eijkel, J.C.T.; Meinhart, C.D.; Pennathur, S.; Electrochim. Acta, 2019, DOI: 10.1016/j.electacta.2019.135275

• Electrochemical Aptamer-based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-controlled Drug Delivery. Dauphin-Ducharme, P.; Yang, K.; Arroyo-Curras, N.; Ploense, K.L.; Zhang, Y.; Gerson, J.; Kurnik, M.; Kippin, T.E.; Stojanovic, M.N.; Plaxco, K.W.; ACA. Sens., 2019, DOI: 10.1021/acssensors.9b01616

• Open Source Software for the Real-Time Control, Processing, and Visualization of High-Volume Electrochemical Data. Curtis, S.D.; Ploense, K.L.; Kurnik, M.; Ortega, G.; Parolo, C.; Kippin, T.E.; Plaxco, K.W.; Arroyo-Currás, N.; Anal. Chem., 2019, DOI: 10.1021/acs.analchem.9b02553

• Ultra-high-precision, in-vivo pharmacokinetic measurements highlight the need for and a route towards more highly personalized medicine. Vieira, P.A.; Shin, C.; Arroyo-Curras, N.; Ortega, G.; Li, W.; Keller, A.A.; Plaxco, K.W.; Kippin, T.E.; Front. Mol. Biosci., 2019, DOI: 10.3389/fmolb.2019.00069

• Seconds-Resolved Pharmacokinetic Measurements of the Chemotherapeutic Irinotecan In Situ in the Living Body. Idili, A.; Arroyo-Curras, N.; Ploense, K.L.; Csordas, A.T.; Kuwahara, M; Kippin, T.E.; Plaxco, K.W.; Chem. Sci., 2019, DOI: 10.1039/c9sc01495k

• Fluorescence-Based Observation of Transient Electrochemical and Electrokinetic Effects at Nanoconfined Bipolar Electrodes. Scida, K.; Eden, A.; Arroyo-Curras, N.; MacKenzie, S; Satik, Y.; Meinhart, C. D.; Eijkel, J. C. T.; Pennathur, S.; ACS Appl. Mater. Interfaces, 2019, DOI: 10.1021/acsami.9b01339

• Modeling Faradaic Reactions and Electrokinetic Phenomena at a Nanochannel-Confined Bipolar Electrode. Eden, A.; Scida, K.; Arroyo-Curras, N.; Eijkel, J. C. T.; Meinhart, C. D.; Pennathur, S.; J. Phys. Chem. C, 2019, DOI: 10.1021/acs.jpcc.8b10473

• High-precision electrochemical measurements of the guanine-, mismatch- and length-dependence of electron transfer from electrode-bound DNA are consistent with a contact-mediated mechanism. Dauphin-Ducharme, P.; Arroyo-Currás, N.; Plaxco, K.W.; J. Am. Chem. Soc., 2019, DOI: 10.1021/jacs.8b11341