Recent Publications




Rodriguez S, Stewart AN, Lei X, Cao X, Little HC, Fong V, Sarver DC, Wong GW. 2019, “PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity.” FASEB J. 2019 Dec;33(12):14748-14759. doi: 10.1096/fj.201901279R.  PMCID: PMC6894076 PubMed  
Le TT, Gao X, Park SH, Lee J, Inman JT, Lee JH, Killian JL, Badman RP, Berger JM, Wang MD., 2019, "Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity," Cell. ;179(3):619-631.e15. doi: 10.1016/j.cell.2019.09.034 PMCID: PMC6899335 PubMed  
Wang Z, Hutcherson SM, Yang C, Jattani RP, Tritapoe JM, Yang YK, Pomerantz JL., 2019, “Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling,” J Biol Chem. 2019 Oct 4;294(40):14648-14660. doi: 10.1074/jbc.RA119.009551. PMCID: PMC6779434 PubMed  
Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN. 2019, “How the mechanobiome drives cell behavior, viewed through the lens of control theory.” J Cell Sci. 2020 Sep 2 132(17). pii: jcs234476. doi: 10.1242/jcs.234476. Review. PMID: 31477578. PMCID: PMC6771144  PubMed.  
Frandolig JE, Matney CJ, Lee K, Kim J, Chevée M, Kim SJ, Bickert AA, Brown SP. 2019 Sep 17. “The Synaptic Organization of Layer 6 Circuits Reveals Inhibition as a Major Output of a Neocortical Sublamina.” Cell Rep. 28(12):3131-3143.e5. doi: 10.1016/j.celrep.2019.08.048. PMID: 31533036. PubMed.  
Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS, Ewald AJ. 2019 Sep. “E-cadherin is required for metastasis in multiple models of breast cancer.” Nature. 573(7774):439-444. doi: 10.1038/s41586-019-1526-3. Epub 2019 Sep 4. PMID: 31485072. PubMed.  
Puddu F, Herzog M, Selivanova A, Wang S, Zhu J, Klein-Lavi S, Gordon M, Meirman R, Millan-Zambrano G, Ayestaran I, Salguero I, Sharan R, Li R, Kupiec M, Jackson SP. 2019 Sep. “Genome architecture and stability in the Saccharomyces cerevisiae knockout collection.” Nature. 573(7774):416-420. doi: 10.1038/s41586-019-1549-9. PMCID: PMC6774800. PubMed.  
Ouyang JPT, Folkmann A, Bernard L, Lee CY, Seroussi U, Charlesworth AG, Claycomb JM, Seydoux G., 2019, “P Granules Protect RNA Interference Genes from Silencing by piRNAs.” Dev Cell. 2019 Sep 23;50(6):716-728.e6. doi: 10.1016/j.devcel.2019.07.026. PMCID: PMC6764750 PubMed  
Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli KT, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN., 2019, “Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14.” Cancer Res. 2019 Sep 15;79(18):4665-4678. doi: 10.1158/0008-5472.CAN-18-3131., PMCID: PMC6744980 PubMed  
Tan Y, Cahan P. 2019 Aug 28. “SingleCellNet: A Computational Tool to Classify Single Cell RNA-Seq Data Across Platforms and Across Species.” Cell Syst.;9(2):207-213.e2. doi: 10.1016/j.cels.2019.06.004. Epub 2019 Jul 31. PMID: 31377170. PMCID: PMC6715530.  PubMed  
Vissers C, Kageyama R. 2019 Aug 19. “Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.” Dev Cell.;50(4):393-394. doi: 10.1016/j.devcel.2019.07.028. PMID: 31430449. PubMed.  
Pike AM, Strong MA, Ouyang JPT, Greider CW. 2019 Aug 5. “TIN2 functions with TPP1/POT1 to stimulate telomerase processivity.” Mol Cell Biol.. pii: MCB.00593-18. doi: 10.1128/MCB.00593-18. PMCID: PMC6791651. PubMed  
Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong X, Wu X, Zhang Y, Snyder SH, Gaudenzio N, Vidal JE, Dong X. 2019 Jul 10. “A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity.” Cell Host Microbe.;26(1):114-122.e8. doi: 10.1016/j.chom.2019.06.003. Epub 2019 Jul 2. PMID: 31278040. PMCID: PMC6649664. PubMed.  
Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. 2019 Jul 23. “Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.” Cell Chem Biol. pii: S2451-9456(19)30218-1. doi: 10.1016/j.chembiol.2019.07.006. [Epub ahead of print] PMID: 31353321. PubMed.  
Bender AM, Simonetti FR, Kumar MR, Fray EJ, Bruner KM, Timmons AE, Tai KY, Jenike KM, Antar AAR, Liu PT, Ho YC, Raugi DN, Seydi M, Gottlieb GS, Okoye AA, Del Prete GQ, Picker LJ, Mankowski JL, Lifson JD, Siliciano JD, Laird GM, Barouch DH, Clements JE, Siliciano RF. 2019 Jul 10. “The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.” Cell Host Microbe.;26(1):73-85.e4. doi: 10.1016/j.chom.2019.06.005. PMID: 31295427. PMCID: PMC6724192 PubMed.  
Edens BM, Vissers C, Su J, Arumugam S, Xu Z, Shi H, Miller N, Rojas Ringeling F, Ming GL, He C, Song H, Ma YC. 2019 Jul 23. “FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.” Cell Rep.;28(4):845-854.e5. doi: 10.1016/j.celrep.2019.06.072. PMID: 31340148. PubMed.  
Hayward D, Kouznetsova VL, Pierson HE, Hasan NM, Guzman ER, Tsigelny IF, Lutsenko S., 2019 Jul 23, “ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly.” J Biol Chem. 2019 Sep 27;294(39):14454-14466. doi: 10.1074/jbc.RA119.008231. PMCID: PMC6768640 PubMed  
Little HC, Rodriguez S, Lei X, Tan SY, Stewart AN, Sahagun A, Sarver DC, Wong GW., 2019, “Myonectin deletion promotes adipose fat storage and reduces liver steatosis” FASEB J. 2019 Jul;33(7):8666-8687. doi: 10.1096/fj.201900520R PMCID: PMC6593887 PubMed  
Johnson DM, Andrew DJ. 2019 Jun 26. “Role of tbc1 in Drosophila embryonic salivary glands.” BMC Mol Cell Biol. 20(1):19. doi: 10.1186/s12860-019-0198-z. PMCID: PMC6595604. PubMed.  
Allen J, Sears CL. 2019 Feb 25. “Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development.” Genome Med. 20(1):19. doi: 10.1186/s12860-019-0198-z. PMID: 30803449. PMCID: PMC6388476. PubMed  
Zhu L*, Liao SE*, Fukunaga R. 2019 Jun 23. “Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis.” RNA Biol. 1-15. doi: 10.1080/15476286.2019.1630799. [Epub ahead of print], PMCID: PMC6542536, *equal contribution. PubMed  
Kodani A, Moyer T, Chen A, Holland A, Walsh CA, Reiter JF. 2019 Jun 13. “SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.” J Cell Biol. pii: jcb.201803041. doi: 10.1083/jcb.201803041. [Epub ahead of print]. PMID: 31197030. PubMed.  
D'Orazio KN, Wu CC, Sinha N, Loll-Krippleber R, Brown GW, Green R. 2019 Jun 20. “The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay.” Elife. 8. pii: e49117. doi: 10.7554/eLife.49117. PMCID: PMC6598757. PubMed.  
Zieman AG, Poll BG, Ma J, Coulombe PA. 2019 Jul 1. “Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.” Hum Mol Genet. 28(13):2255-2270. doi: 10.1093/hmg/ddz050. PMCID: PMC6602407. PubMed  
Dresselhaus EC, Meffert MK., 2019 May 9. "Cellular Specificity of NF-κB Function in the Nervous System." Front Immunol, 10:1043. doi: 10.3389/fimmu.2019.01043. eCollection 2019. Review. PMCID: PMC6520659. PubMed.
Weaver J, Mohammad F, Buskirk AR, Storz G, 2019 Mar 5. "Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes." MBio, 10(2). pii: e02819-18. doi: 10.1128/mBio.02819-18. PMCID: PMC6401488. PubMed.
Meixiong J, Vasavda C, Snyder SH, Dong X., 2019 May 21. "MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus." Proc Natl Acad Sci USA, 116(21):10525-10530. doi: 10.1073/pnas.1903316116. PMCID: PMC6535009 PubMed.
DeFelice MM*, Clark HR*, Hughey JJ*, Maayan I, Kudo T, Gutschow MV, Covert MW, Regot S., 2019 Apr 30. "NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop." Sci Signal. 12(579). pii: eaau3568. doi: 10.1126/scisignal.aau3568. *equal contribution. PubMed.
Moyer TC, Holland AJ., 2019 May 22. "PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall." Elife, 8. pii: e46054. doi: 10.7554/eLife.46054. [Epub ahead of print]. PMCID: PMC6570480  PubMed.
Zhu L, Liao SE, Ai Y, Fukunaga R, 2019 May 30. "RNA methyltransferase BCDIN3D is crucial for female fertility and miRNA and mRNA profiles in Drosophila ovaries.", PLoS One.14(5):e0217603. doi: 10.1371/journal.pone.0217603. eCollection 2019. PMCID: PMC6542536 PubMed.
Syu GD, Wang SC, Ma G, Liu S, Pearce D, Prakash A, Henson B, Weng LC, Ghosh D, Ramos P, Eichinger D, Pino I, Dong X, Xiao J, Wang S, Tao N, Kim KS, Desai PJ, Zhu H., 2019 Apr 30, "Development and application of a high-content virion display human GPCR array." Nat Commun.;10(1):1997. doi: 10.1038/s41467-019-09938-9. PMCID: PMC6491619  PubMed.
Latallo MJ, Livingston NM, Wu B., 2019, “Translation imaging of single mRNAs in established cell lines and primary cultured neurons.” Methods. 2019 Jun 1;162-163:12-22. doi: 10.1016/j.ymeth.2019.03.021. Epub 2019 Mar 21. Review. PMID: 30905747 PubMed  
Bowman CE, Scafidi J, Scafidi S., 2019, ”Metabolic perturbations after pediatric TBI: It's not just about glucose”, Exp Neurol. Review. 316:74-84. PubMed  
Clister T, Greenwald EC, Baillie GS, Zhang J., 2019 Jun 20, “AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA”, Cell Chem Biol. 26(6):885-891.e4. doi: 10.1016/j.chembiol.2019.03.003. PMCID: PMC6588460. PubMed  
Bowman CE, Selen Alpergin ES, Ellis JM, Wolfgang MJ., 2019 Nov 1, “Loss of ACOT7 potentiates seizures and metabolic dysfunction”, Am J Physiol Endocrinol Metab. 317(5):E941-E951. doi: 10.1152/ajpendo.00537.2018. PMCID: PMC6879868. PubMed  
Liao SE, Kandasamy SK, Zhu L, Fukunaga R. 2019 Jul.”DEAD-box RNA helicase Belle posttranscriptionally promotes gene expression in an ATPase activity-dependent manner.” RNA.;25(7):825-839. doi: 10.1261/rna.070268.118. Epub 2019 Apr 12. PMID: 30979781. PMCID: PMC6573787. PubMed.  
Lariviere PJ, Mahone CR, Santiago-Collazo G, Howell M, Daitch AK, Zeinert R, Chien P, Brown PJB, Goley ED., 2019, “An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation”, Curr Biol. pii: S0960-9822(19)30394-X. PubMed  
Patel SP, Vasavda C, Ho B, Meixiong J, Dong X, Kwatra SG., 2019, “Cholestatic pruritus: Emerging mechanisms and therapeutics”, J Am Acad Dermatol. pii: S0190-9622(19)30627-9. Review. PubMed  
Cook EK, Sell GL, Schaffer TB, Margolis SS., 2019 Apr, "The emergence of Ephexin5 as a therapeutic target in Alzheimer's disease." Expert Opin Ther Targets. 23(4):263-265. PMCID: PMC6715421 PubMed
Calzada, E.,Avery E, Sam PN, Modak A, Wang C, McCaffery JM, Han X, Alder NN, Claypool SM., 2019, "Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function." Nat Commun. 10(1):1432 PMCID: PMC6441012 PubMed
Putnam A, Cassani M, Smith J, Seydoux G. 2019, "A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos," Nat Struct Mol Biol. (3):220-226. doi: 10.1038/s41594-019-0193-2. Epub 2019 Mar 4. PMID: 30833787. PMCID: PMC6668929  PubMed  
Allen J, Hao S, Sears CL, Timp W., 2019, "Epigenetic changes induced by Bacteroides fragilis toxin (BFT)." Infect Immun. pii: IAI.00447-18. PubMed
Westerbeck JW, Machamer CE., 2019, "The Infectious Bronchitis Coronavirus Envelope Protein Alters Golgi pH to Protect Spike Protein and Promote Release of Infectious Virus." J Virol.  pii: JVI.00015-19. PubMed
Yue WWS*, Silverman D*, Ren X, Frederiksen R, Sakai K, Yamashita T, Shichida Y, Cornwall MC4, Chen J, Yau KW., 2019 "Elementary response triggered by transducin in retinal rods." Proc Natl Acad Sci U S A. 116(11):5144-5153 PMCID: PMC6421417 *equal contribution PubMed
Bartee D, Sanders S, Phillips PD, Harrison MJ, Koppisch AT, Freel Meyers CL., 2019, "Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents." ACS Infect Dis. 5(3):406-417, PMCID: PMC6592275.  PubMed  
Worden EJ, Hoffmann NA, Hicks CW, Wolberger C. 2019 Mar 7. “Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.” Cell.;176(6):1490-1501.e12. doi: 10.1016/j.cell.2019.02.002. Epub 2019 Feb 11. PMID: 30765112. PMCID: PMC6498860. PubMed.  
Schiffhauer, ES., Ren, Y., Iglesias, V., Kothari, P., Iglesias, PA. and Robinson, DN., 2019, "Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics," J. Cell Biol.218(3):895-908, PMCID: PMC6400566. PubMed  
Vissers C, Ming GL, Song H., 2019, "Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders." Adv Drug Deliv Rev. pii: S0169-409X(19)30023-7. PubMed
Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G., 2019, "Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants." Dev Cell. 48(3):406-419.e5. PubMed  
Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H., 2019, "Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis." Cancer Cell. 35(2):315-328.e6. PMID: 30753828. PMCID: PMC6636642. PubMed