Photo of Jiou Wang

Jiou Wang

We are interested in the biological basis for protein and RNA homeostasis in neurodegeneration. We hope to solve problems that not only have biological significance but also have important implications for understanding and treating disease. Discovering key regulators of...

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Danfeng Cai

The Cai lab focuses on understanding how the transcription process is regulated in normal and cancer cells. We are intrigued by the discoveries in our lab that many transcription factors involved in cancers can form small, liquid-like condensates in...

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Photo of Taeyoung Hwang

Taeyoung Hwang

RNA is typically understood as an intermediary molecule between DNA and protein. But, many noncoding RNAs, as well as the noncoding regions of messenger RNA, are increasingly appreciated as important regulators of gene expression and cellular functions. The forefront...

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Image of Shuying Sun

Shuying Sun

RNA metabolism dysfunction and RNA-targeting therapy in neurodegeneration The nervous system has extremely complex RNA processing regulation. Dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are...

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Chang Liu

We study the molecular mechanisms underlying a variety of nucleic acid transactions, including DNA transposition, RNA synthesis and RNA processing. The current research focus of my laboratory is to understand the molecular underpinnings and biological significance of complex virus-host...

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Genevieve Stein-O’Brien

Single cell gene molecular profiling has demonstrated that cell classification requires more than a simple collection of markers. Current approaches do not account for the dynamic nature of cell states and inherent variation in cell types. This is especially...

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Luisa Cochella

The evolution of multicellularity occurred hand in hand with the diversification of cell types with disparate morphologies and functions. This segregation of function across different cell types enabled astounding animal complexity; but at the same time, extreme specializations of...

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Kebschull, Justus

Understanding the brain using evolution, viruses, and barcode sequencing. Our research aims to understand the structure and function of the brain. To do so, we take a comparative approach and develop molecular, viral, and sequencing technologies to measure neuronal...

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Bindu Paul

Redox regulation plays a central role in signal transduction processes operating in the brain. Aberrant redox signaling is a hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis and various Ataxias. It...

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Jun Liu

Our primary research interest lies at the interface between chemistry, biology and medicine. We seek to discover new chemical ligands to modulate signaling pathways and cellular processes of interest by conducting high-throughput screening of chemical libraries we generate or...

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