We study how epithelial tubular organs – which are essential to life in all multicellular organisms – form and specialize. Using the simple unbranched tubes of the Drosophila salivary gland and the beautifully branched tubular network of the Drosophila...
What are cellular and molecular mechanisms that control tissue regeneration in vivo? Stem cells ensure tissue renewal in most adult tissues, and their activities are under the precise control of signals from specific local microenvironments, or niches. The ability...
We study fundamental cellular processes relevant to human disease. A major research focus in our laboratory is the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS), which results from a mutation in the gene encoding the nuclear scaffold protein lamin...