OR
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment
Structural enzymology of redox and phosphoryl-transfer enzymes. Selected areas of channels and transporters.
Building body parts – discovering the mechanisms by which organs achieve their unique architectures and physiological specializations during embryonic development
Structural and molecular mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure
Role of drug metabolism in non-nucleoside reverse transcriptase inhibitor-mediated toxicity
Hybrid experimental/ computational lab studying gene regulatory networks in development, stem cell engineering, and cancer
Molecular and Cellular Mechanisms of Pain Sensation
Functional interactions of proteins in human health and disease.
Fungal pathogenesis: the host-pathogen interaction for the yeast pathogen Candida glabrata
Molecular mechanisms of neuronal death and survival in models of stroke, Parkinson's and Alzheimer’s disease
Cell specification and differentiation in the mammalian auditory system
Molecular and Cellular Studies of Somatosensation, Inflammation, and related diseases
Mechanisms of Molecular Sensing
Cellular mechanisms and molecular regulation of epithelial morphogenesis during development and breast cancer
Epigenetics in development and disease
Medicinal chemistry, chemical biology, drug delivery, bacterial isoprenoid and vitamin and biosynthesis, design of anti-infective strategies
NMR studies of active enzymatic systems: dynamic molecular communication in Nonribosomal Peptide Synthetases
Zinc physiology with a focus on structure, function and regulation of zinc transporters
Bacterial cell biology: growth, division, and shape regulation
Mechanisms of Ribosome Translation and Translational Control
Telomeres and telomerase in stem cell failure and cancer
Genetic disorders associated with defective fluid and electrolyte movement; ion channel and epithelial transport physiology
Molecular mechanisms of programmed cell death and its role in viral pathogenesis
Molecular mechanisms underlying accurate chromosome segregation and centrosome duplication
Regulation of neurotransmitter receptors and brain function in health and disease
Synthetic cell biology: total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
Regulatory pathways that control adaptive metabolic responses in adipose and skeletal muscle tissues
Theoretical modeling, Mechanobiology, Cell Migration, Membrane trafficking, Cell Division
Chemical biology and molecular biology; use of small molecules to probe important cellular processes and pathways; translational medicine
Human copper homeostasis: mechanism of copper transport, regulatory networks, the role in lipid metabolism, disorders of copper misbalance
Molecular Mechanisms of Synapse Formation in Development and Disease
Regulation of experience-dependent gene expression in brain circuits that control behavior
The Regulation of Neuronal Gene Expression in Health and Disease
The premature aging disease progeria and lamin A processing; ubiquitin-proteasome mediated protein quality control.
Auditory Perception and Development of Neocortical Circuits
Molecular mechanisms of retinal development and disease; the role of Frizzled receptors in mammalian development
Molecular dissection of host-pathogen interactions and the evolution of virulence strategies in natural reservoirs
Elucidating the role of sensory receptors, such as olfactory receptors, in regulating renal function
Functional Specificity and Design of Signal Transduction Pathways
Structure, regulation, interfacial enzymology, and functions of lipid metabolizing enzymes involved in signal transduction cascades
Ion transport in health and disease. Emerging roles for Ca2+ signaling and endosomal pH in cancer, autism and neurodegenerative disorders
Understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation
Molecular mechanisms of signal transduction and neurogenesis in the olfactory system
Characterize and treat the development and functional consequences of trisomy in Down Syndrome using model systems, human genetic studies, cell and molecular approaches
Molecular basis of cell-cell interactions in the nervous and immune systems; glycobiology
Molecular Mechanisms and Physiological Roles of Mitochondrial Fusion and Division
Discovery, development and clinical trials of drugs for malaria and sleeping sickness; in vitro pharmacokinetics-pharmacodynamics; long-acting chemoprophylaxis
Mechanisms of immune surveillance and immunotherapy; Molecular mechanisms of antigen processing and presentation
Neurotransmitters, Second Messengers and Drug Action in the Nervous System
Mechanisms of differentiation and degeneration in the nervous system
Understanding how biological stress-sensors are assembled, detect danger signals, and initiate stress-response
Structure and function of the genes and gene products of the mammalian major histocompatibility complex
Epigenetic pathways in disease, histone and chromatin modifications, and small RNA directed gene silencing
Sequencing Technology Development and Application to Genetics, Epigenetics and Transcriptomics
Structural and molecular mechanisms of neurotransmission and protein homeostasis.
Cellular and molecular characterizations of rapid changes during synaptic plasticity
Nuclear envelope, lamins and nucleoskeleton; Emery-Dreifuss muscular dystrophy
Structural and molecular mechanisms of ubiquitin signaling and chromatin modification; regulation of transcription
Chromatin remodeling as a fundamental regulator of gene activity
Single-molecule and single-cell studies of cell division, chromosome conformation, transcription and gene regulation
O-GlcNAc, A Novel Regulator of the Cellular Stress Response and Cell Surival
Signal Transduction, protein network, host-pathogen interaction, protein chip approach to study proteomics