Geraldine Seydoux
Professor
Molecular Biology and Genetics
Developmental genetics: RNA and protein dynamics in embryos
725 N. Wolfe Street
706 PCTB
Baltimore MD 21205
Our lab studies gene regulation in germ cells, with a focus on “RNA granules” which are phase-separated compartments rich in RNA and proteins. We have identified a family of intrinsically-disordered proteins that form gel-like assemblies that sequester RNA (RNA granules) in the cytoplasm. We use genetics, microscopy and biochemistry to identify, observe and reconstitute RNA granules in and out of cells. We have also developed methods for scalable and seamless genome editing using CRISPR/Cas9.