Richard Ambinder
1650 Orleans Street
Room 389 CRB1
Baltimore MD 21287
Epstein-Barr virus and Kaposi’s sarcoma herpesvirus are found in association with a variety of cancers. Our laboratory studies are aimed at better defining the role(s) of the virus in the pathogenesis of these diseases and the development of strategies to prevent, diagnose or treat them. We have become particularly interested in the unfolded protein response in activation of latent viral infection. Among the notions that we are exploring is the possibility that activation of virus-encoded enzymes will allow the targeted delivery of radiation. In addition, we are investigating a variety of virus-related biomarkers including viral DNA, antibody responses, and cytokine measurements that may be clinically relevant.
Alvarnas JC, Le Rademacher J, Wang Y, Little RF, Akpek G, Ayala E, Devine S, Baiocchi R, Lozanski G, Kaplan L, Noy A, Popat U, Hsu J, Morris LE Jr, Thompson J, Horowitz MM, Mendizabal A, Levine A, Krishnan A, Forman SJ, Navarro WH, Ambinder R. Autologous hematopoietic cell transplantation for HIVrelated lymphoma: results of the BMT CTN 0803/AMC 071 trial. Blood. 2016 Aug 25;128(8):10508. doi: 10.1182/blood201508664706. Epub 2016 Jun 13. PMID: 27297790
Kanakry JA, Hegde AM, Durand CM, Massie AB, Greer AE, Ambinder RF, Valsamakis A. The clinical significance of EBV DNA in the plasma and peripheral blood mononuclear cells of patients with or without EBV diseases. Blood. 2016 Apr 21;127(16):200717. doi: 10.1182/blood201509672030.Epub 2016 Jan 7. PMID: 26744460
Kalu NN, Desai PJ, Shirley CM, Gibson W, Dennis PA, Ambinder RF. Nelfinavir inhibits maturation and export of herpes simplex virus 1. J Virol. 2014 May;88(10):545561. doi: 10.1128/JVI.0379013. Epub 2014 Feb 26. PMID: 24574416 Free PMC Article
Kasamon YL, Jacene HA, Gocke CD, Swinnen LJ, Gladstone DE, Perkins B, Link BK, Popplewell LL, Habermann TM, Herman JM, Matsui WH, Jones RJ, Ambinder RF. Phase 2 study of rituximabABVD in classical Hodgkin lymphoma. Blood. 2012 May 3;119(18):412932. doi: 10.1182/blood201201402792. Epub 2012 Feb 16. PMID: 22343727 Free PMC Article
Durand CM, Ghiaur G, Siliciano JD, Rabi SA, Eisele EE, Salgado M, Shan L, Lai JF, Zhang H, Margolick J, Jones RJ, Gallant JE, Ambinder RF, Siliciano RF. HIV1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy. J Infect Dis. 2012 Mar 15;205(6):10148. doi: 10.1093/infdis/jir884. Epub 2012 Jan 24. PMID: 22275402 Free PMC Article
Shirley CM, Chen J, Shamay M, Li H, Zahnow CA, Hayward SD, Ambinder RF. Bortezomib induction of C/EBPβ mediates EpsteinBarr virus lytic activation in Burkitt lymphoma. Blood. 2011 Jun 9;117(23):6297303. doi: 10.1182/blood201101332379. Epub 2011 Mar 29. PMID: 21447826 Free PMC Article
Lin L., Lee JY., Kaplan LD., Dezube BJ., Noy A., Krown SE, Levine AM, Yu Y, Hayward GS, Ambinder R.F., Effects of Chemotherapy in AIDS-Associated Non-Hodgkin’s Lymphoma on KSHV DNA in Blood. J Clin Oncol. 27: 2496-502, 2009.
Fu, D., Tanhehco Y., Chen J., Foss CA., Fos JF., Chong J, Hobbs RF., Fukayama M., Sgouros G., Kowalski, J., Pomper, MG., Ambinder, R.F., Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat Med. 14:1118-22, 2008.