Our research seeks to map and engineer cell fate using synthetic biology and genomics approaches. To accomplish this objective, we develop: (A) molecular technologies that write cellular histories into their genomes, (B) sequencing strategies that read out written information with spatial resolution, and (C) computational methods that reconstruct the underlying biological processes based on recorded information. We apply these approaches to study embryogenesis, neurogenesis, and cancer metastasis, where we also aim to establish more effective cell therapies.