Our laboratory studies the molecular and cellular mechanisms underlying the perception of pain under healthy conditions and in the setting of pathology.  Towards this goal, we utilize a wide spectrum of approaches including behavioral analysis, in vivo and in vitro imaging and electrophysiology, genome editing, image analysis, transcriptomics, biochemistry, and cell biology. Current areas of interest in the lab include: 1) Molecular contributors to pain in hereditary skin disorders; 2) miRNA functions in the setting of neuropathic pain; 3) Interactions between injured nerves and nearby spared neurons; 4) Re-engineering signal transduction pathways to modulate pain; 5) Cellular and molecular contributors to arthritis pain.