Michael Caterina
725 N. Wolfe Street
408 Biophysics Building
Baltimore, MD 21205
Our laboratory studies the molecular and cellular mechanisms underlying the perception of pain under healthy conditions and in the setting of pathology. Towards this goal, we utilize a wide spectrum of approaches including behavioral analysis, in vivo and in vitro imaging and electrophysiology, genome editing, image analysis, transcriptomics, biochemistry, and cell biology. Current areas of interest in the lab include: 1) Molecular contributors to pain in hereditary skin disorders; 2) miRNA functions in the setting of neuropathic pain; 3) Interactions between injured nerves and nearby spared neurons; 4) Re-engineering signal transduction pathways to modulate pain; 5) Cellular and molecular contributors to arthritis pain.
Li X., Eadara S., Jeon S. Liu Y., Muwanga G., Qu L., Caterina M.J., and Meffert, M.K. (2021) Combined single-molecule fluorescence in-situ hybridization and immunohistochemistry analysis in intact dorsal root ganglia and sciatic nerve. STAR Protoc. 2021 Jun 3;2(2):100555. https://pubmed.ncbi.nlm.nih.gov/34142098/
Jeon, S., Chang, D., Geske, A., Ginty, D.D., and Caterina, M.J. Sex-Dependent Reduction in Mechanical Allodynia in the Sural-Sparing Nerve Injury Model in Mice Lacking Merkel Cells. J Neurosci. 2021 Jun 30;41(26):5595-5619. https://pubmed.ncbi.nlm.nih.gov/34031166/
Liu U., Jeon S-M, Caterina MJ, and Qu L. (2021) miR-544-3p mediates arthritis pain through regulation of FcgammaRI. bioRxiv 2021.06.13.448256; doi: https://doi.org/10.1101/2021.06.13.448256
Joseph J., Qu L., Wang S., Kim M., Bennett D., Ro J., Caterina M., and Chung M.K. Phosphorylation of TRPV1 S801 contributes to modality-specific hyperalgesia in mice (2019) J. Neuroscience Dec 11;39(50):9954-9966. https://pubmed.ncbi.nlm.nih.gov/31676602/
Wang L., Jiang X., Zheng Q., Jeon S.M., Chen T., Kulaga H., Reed R., Dong X., Caterina M.J., and Qu L. Neuronal FcgRI mediates acute and chronic joint pain through a noninflammatory mechanism J Clin Invest. 2019 Jun 18;130. pii: 128010. doi: 10.1172/JCI128010. PMID:31211699
Jeon S, Caterina MJ (2018) Peripheral Mechanisms of Warmth Transduction. In: Thermoregulation, Elsevier, A. Romanovsky Ed. Handb Clin Neurol. 156:69-82. PMID:30454610
Weinberg, R.L., Polydefkis, M., Coulombe, P.A., and Caterina, M.J. Pain mechanisms in hereditary palmoplantar keratodermas Mar 18. doi: 10.1111/bjd.17880. [Epub ahead of print] Review. PMID:30883689
Pan, B., Byrnes, K., Schwartz, M., Hansen, C.D., Campbell, C., Krupiczojc, M., Caterina, M., and Polydefkis, M. (2016) Peripheral neuropathic changes in Pachyonychia Congenita Pain Dec;157(12):2843-2853.PMID: 27776012
Qu L, Caterina MJ. (2016) Enhanced excitability and suppression of A-type K(+) currents in joint sensory neurons in a murine model of antigen-induced arthritis. Sci Rep. 2016 Jul 1;6:28899. PMID: 27363579
Munns CH, Chung MK, Amzel LM, and Caterina MJ. (2015) Role of the outer pore domain in TRPV1 dynamic permeability to large cations. J. Biol Chem. 290: 5707-5724. PMID: 25568328
Pang Z, Sakamoto T, Kim YS, Yang F, Guan Y, Dong X, Guler A, Caterina MJ. Keratinocyte stimulation is sufficient to evoke nociception in the mouse (2015) Pain Apr;156(4):656-65. (cover article) PMID: 25790456
Caterina MJ (2014) TRP channel cannabinoid targets and skin inflammation ACS Chem Neurosci. 5(11):1107-16 PMID: 24915599
Park U, Vastani N, Guan Y, Raja S, Koltzenberg M. and Caterina MJ. TRPV2 knockout mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception (2011) J Neurosci. 31(32):1142PubMed Reference
Huang SM, Li X, Yu Y, Wang J, Caterina MJ. TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. (2011) Mol Pain. 2011 May 17;7(1):37. PubMed Reference
Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. (2010) Nature Immunology 11, 232-239. PubMed Reference
Huang SM, Lee H, Chung MK, Park, U, Yu YY, Bradshaw H, Coulombe PA, Walker JM, and Caterina MJ. Skin keratinocyte TRPV3 ion channels modulate pain sensitivity via prostaglandin E2. (2008) J. Neurosci. 28, 13727- 13737. PubMed Reference
Chung MK, Guler AD and Caterina MJ. TRPV1 exhibits dynamic ionic selectivity during agonist stimulation. (2008) Nature Neuroscience 11, 555-564 (Highlighted in Nat Neurosci. 2008 May;11(5):528-9) PubMed Reference
Lumpkin EA and Caterina MJ. Mechanisms of Sensory Transduction in the Skin. (2007) Nature 445(7130):858-65. PubMed Reference
Shimizu I, Iida T, Horiuchi N and Caterina MJ. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial TRPV1 agonist in vitro .(2005) J. Pharm. Exp. Ther., 314:1378-85. PubMed Reference
Shimizu I, Iida T, Guan Y, Zhao C, Raja SN, Jarvis MF, Cockayne DA, and Caterina MJ. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. (2005) Pain, 116, 96-108. PubMed Reference
Chung MK, Guler AD, and Caterina MJ. Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. (2005) J. Biol Chem. 280, 15928-15941. PubMed Reference
Lee H, Iida T, Mizuno A, Suzuki M, Caterina MJ. Altered thermal preference in mice lacking TRPV4. (2005) J. Neurosci. 25 1304-10. PubMed Reference
Iida T, Shimizu I, Nealen ML, Campbell, A., and Caterina MJ. Attenuated fever response in mice lacking TRPV1. (2005) Neurosci. Lett. 378, 28-33. PubMed Reference
Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ. 2-aminonethoxydiphenyl borate activates and sensitizes the heat-gated ion channel, TRPV3. (2004) J. Neurosci. 24, 5177-5182. PubMed Reference
Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ . TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. (2004) J Biol. Chem. 279, 21569-21575. PubMed Reference
Nealen M, Thut P, Gold M and Caterina MJ. TRPM8 is expressed in a subset of cold-responsive trigeminal neurons from rat. (2003) J. Neurophysiology 90, 515-520. PubMed Reference
Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina M.J. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. (2002) Nature Neurosci. 5, 856-860. PubMed Reference
Guler A, Lee H, Iida T, Shimizu I, Tominaga M, and Caterina MJ. Heat-evoked activation of the ion channel, TRPV4. (2002) J. Neurosci. 22, 6408-6414. PubMed Reference
Caterina MJ, Leffler A, Malmberg A, Martin W, Trafton J, Petersen-Zeitz KR, Koltzenberg M, Basbaum A and Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313. (cover article) PubMed Reference
Caterina MJ, Rosen A, Tominaga M, Brake AJ, and Julius D (1999) A capsaicin receptor homologue with a threshold for noxius heat. Nature, 398, 436-441. PubMed Reference
Caterina MJ, Schumacher M, Tominaga M,, Rosen TA, Levine JD and Julius, D. The capsaicin receptor, a heat-activated ion channel in the pain pathway. (1997) Nature, 389, 816-824. PubMed Reference