Gregory V. Carr

Associate Professor


855 N. Wolfe Street
Rangos 373
Baltimore, MD  21205

Pharmacology and Molecular Sciences

Su Y, DePasquale M, Liao G, Buchler I, Zhang G, Byers S, Carr GV, Barrow J, Wei H. Membrane bound catechol-O-methyltransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain. Eur J Pharmacol. 2021: 896: 173909. 

Noback M, Zhang G, White N, Barrow JC, Carr GV. Post-weaning social isolation increases ΔFosB/FosB protein experession in sex-specific patterns in the prelimbic/inframlimbic cortex and hippocampus in mice. Neurosci Lett. 2021; 740: 135423.

Byers S, Buchler IP, DePasquale M, Rowley HL, Kulkarni RS, Pinder L, Kolobova A, Li C, Au V, Akuma D, Zhang G, Wei H, Cheetham SC, Barrow JC, Carr GV. Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility. Psychopharmacology. 2020; 237(9): 2695-2707. 

Ernst G, Akuma D, Au V, Buchler IP, Byers S, Carr GV, Defays S, de Leon P, Demaude T, DePasquale M, Durieu V, Huang Y, Jigorel E, Kimos M, Kolobova A, Montel F, Moureau F, Poslusney M, Swinnen D, Vandergeten M-C, Van houtvin N, Wei H, White N, Wood M, Barrow JC. Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol-O-Methyltransferase. ACS Med. Chem. Lett. 2019; 10(11): 1573-1578.

Zhang G, Buchler IP, DePasquale M, Wormald M, Liao G, Wei H, Barrow JC, Carr GV. Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors. ACS Chemical Neurosci. 2019; 10(10):4221-4226.

Buchler I, Akuma D, Au V, Carr G, de Leon P, DePasquale M, Ernst G, Huang Y, Kimos M, Kolobova A, Poslusney M, Wei H, Swinnen D, Montel F, Moureau F, Jigorel E, Schulze MED, Wood M, Barrow JC. Optimization of 8-Hydroxquinolines as Inhibitors of Catechol-O-Methyltransferase. J Med Chem. 2018; 61(21): 9647-9665.
Carr GV, Maltese F, Sibley DR, Weinberger DR, Papaleo F. The Dopamine D5 Receptor is Involved in Working Memory. Front Pharmacol. 2017: 8:666.
Carr, G.V., Chen, J., Yang, F., Ren, M., Yuan, P., Tian, Q., Bebensee, A., Zhang, G.Y., Du, J., Glineburg, P., Xun, R., Akhile, O., Akuma, D., Pickel, J., Barrow, J.C., Papaleo, F., Weinberger, D.R. KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. Mol Psychiatry 2016 Nov; 21(11): 1517-1526.
Carr, G.V.*, Jenkins, K.A.*, Weinberger, D.R., Papaleo, F. Loss of dysbindin‐1 in mice impairs reward‐based operant learning by increasing impulsive and compulsive behavior. Behav Brain Res. 2013; 241: 173-184. *These authors contributed equally to this work.