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Photo of Benjamin Koleske

Benjamin Koleske

bkolsk1@jhmi.edu

Publications

Koleske B )Elimination of senescent cells…)

Shee S, Martinez-Martinez YB, Koleske B, Shaku MT, Yabaji S, Kobzik L, Kramnik I, Bishai W., 2026, Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice, Nat Commun., doi: 10.1038/s41467-026-72874-y. PMID: 42098153  PubMed

Koleske B (Loss of the ESX-5 secretion locus…)

Koleske B, Rajagopalan S, Schill C, Lun S, Vilchèze C, Das L, Gupta M, Martinez-Martinez YB, Bishai WR, Jacobs WR Jr., 2025, Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion, Proc Natl Acad Sci U S A, 122(36):e2509997122. doi: 10.1073/pnas.2509997122. PMCID: PMC12435201  PubMed

Koleske B (Loss of the PPE71-esxX-esxY-PPE38…)

Koleske B, Schill C, Rajagopalan S, Shee S, Martinez-Martinez YB, Gupta M, Shen J, Jacobs WR Jr, Bishai WR., 2025, Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2, Sci Adv., 11(27):eadw5194. doi: 10.1126/sciadv.adw5194. PMCID: PMC12219505  PubMed

Koleske B (In vivo profiling of the PE/PPE..)

Koleske B, Shen J, Gupta M, Bishai WR., 2025, In vivo profiling of the PE/PPE proteins of Mycobacterium tuberculosis reveals diverse contributions to virulence, Front Microbiol., 16:1634229. doi: 10.3389/fmicb.2025.1634229. PMCID: PMC12213770  PubMed

Koleske B (Structure-based virtual…)

Rohilla A, Singh AK, Koleske B, Srikrishna G, Bishai WR., 2023, Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP, Microbiol Spectr., e0201223. doi: 10.1128/spectrum.02012-23. PMID: 38095464  PubMed

Koleske B (Glutamine metabolism inhibition..)

Parveen S, Shen J, Lun S, Zhao L, Alt J, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, Bishai WR., 2023, Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis, Nat Commun., 14(1):7427. doi: 10.1038/s41467-023-43304-0, PMCID: PMC10654700  PubMed

KoleskeBN (The Mycobacterium tuberculosis..)

Koleske BN, Jacobs WR Jr, Bishai WR., 203, The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions, J Clin Invest., 133(19):e173156. doi: 10.1172/JCI173156. PMCID: PMC10541200  PubMed

Koleske B, Translational repression

Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R., 2021, Translational repression of NMD targets by GIGYF2 and EIF4E2, PLoS Genet., 17(10):e1009813. doi: 10.1371/journal.pgen.1009813. PMCID: PMC8555832  PubMed