Reza Kalhor

Our research seeks to better understand dynamical biological processes, such as embryonic development and brain activity, by recording cells’ experiences in their genomes. To accomplish this objective, we develop: (A) molecular technologies that write cellular experiences into their nucleic acids, (B) sequencing strategies that read out written information with high spatial resolution, and (C) computational methods that reconstruct the underlying biological processes based on recorded information. We combine these recording approaches with genomics and epigenomics strategies to study early development, neurodevelopment, brain function, and cancer metastasis. Consequently, our work resides at the interface of biology and technology and involves both experimental and computational expertise.