People

James Saba

James Saba

jsaba1@jhmi.edu

Publications

2025 Young Investigators Day: The Nupur Dinesh Thekdi Research Award/James Saba

2025 Young Investigators Day: The Nupur Dinesh Thekdi Research Award

Huso VL, Saba JA (ZAK activation at the collided…)

Huso VL, Niu S, Catipovic MA, Saba JA, Denk T, Park E, Cheng J, Berninghausen O, Becker T, Green R, Beckmann R., 2026, ZAK activation at the collided ribosome, Nature, 649(8098):1051-1060. doi: 10.1038/s41586-025-09772-8. PMCID: PMC12823453  PubMed

Saba JA, Schole KL (LARP1 binds ribosomes…)

Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R., 2024, LARP1 binds ribosomes and TOP mRNAs in repressed complexes, EMBO J., 43(24):6555-6572. doi: 10.1038/s44318-024-00294-z. PMCID: PMC11649897  PubMed

Saba JA (Functional diversity…)

Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM., 2024, Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier, EMBO J., 43(14):2979-3008. doi: 10.1038/s44318-024-00132-2. PMCID: PMC11251061  PubMed

Saba JA, Schole KL (LARP1 senses free..)

Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R., 2023, LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins, bioRxiv, 2023.11.01.565189. doi: 10.1101/2023.11.01.565189, PMCID: PMC10635049  PubMed

Livingston NM, Saba JA, Nelson B, Wolfe C

Livingston NM, Kwon J, Valera O, Saba JA, Sinha NK, Reddy P, Nelson B, Wolfe C, Ha T, Green R, Liu J, Wu B., 2023, Bursting translation on single mRNAs in live cells, Mol Cell., 83(13):2276-2289.e11. doi: 10.1016/j.molcel.2023.05.019, PMCID: PMC10330622  PubMed

Saba JA, Evolutionarily conserved inhibitory

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE., 2022, Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency, Proc Natl Acad Sci U S A., 119(9):e2117226119. doi: 10.1073/pnas.2117226119. PMCID: PMC8892498  PubMed

Saba JA, “translational control of stem..”

Saba JA, Liakath-Ali K, Green R, Watt FM., 2021, Translational control of stem cell function, Nat Rev Mol Cell Biol., doi: 10.1038/s41580-021-00386-2. Epub ahead of print. PMID: 34272502.  PubMed

2021 NIH F30 Predoctoral Fellowship

2021 NIH F30 Predoctoral Fellowship

Saba01

Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R., 2020, “EDF1 coordinates cellular responses to ribosome collisions.” Elife. 2020 Aug 3;9:e58828. doi: 10.7554/eLife.58828. PMID: 32744497; PMCID: PMC7486125. PubMed

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