James Saba


BA, University of Virginia

Green Lab

Associated BCMB Faculty Member(s)

Name Lab Website
Rachel Green Lab website

Publications

  • Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R., 2024, LARP1 binds ribosomes and TOP mRNAs in repressed complexes, EMBO J., 43(24):6555-6572. doi: 10.1038/s44318-024-00294-z. PMCID: PMC11649897  PubMed
  • Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM., 2024, Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier, EMBO J., 43(14):2979-3008. doi: 10.1038/s44318-024-00132-2. PMCID: PMC11251061  PubMed
  • Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R., 2023, LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins, bioRxiv, 2023.11.01.565189. doi: 10.1101/2023.11.01.565189, PMCID: PMC10635049  PubMed
  • Livingston NM, Kwon J, Valera O, Saba JA, Sinha NK, Reddy P, Nelson B, Wolfe C, Ha T, Green R, Liu J, Wu B., 2023, Bursting translation on single mRNAs in live cells, Mol Cell., 83(13):2276-2289.e11. doi: 10.1016/j.molcel.2023.05.019, PMCID: PMC10330622  PubMed
  • Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE., 2022, Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency, Proc Natl Acad Sci U S A., 119(9):e2117226119. doi: 10.1073/pnas.2117226119. PMCID: PMC8892498  PubMed
  • Saba JA, Liakath-Ali K, Green R, Watt FM., 2021, Translational control of stem cell function, Nat Rev Mol Cell Biol., doi: 10.1038/s41580-021-00386-2. Epub ahead of print. PMID: 34272502.  PubMed
  • Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R., 2020, “EDF1 coordinates cellular responses to ribosome collisions.” Elife. 2020 Aug 3;9:e58828. doi: 10.7554/eLife.58828. PMID: 32744497; PMCID: PMC7486125. PubMed

Awards and Distinctions

  • 2025 Young Investigators Day: The Nupur Dinesh Thekdi Research Award
  • 2021 NIH F30 Predoctoral Fellowship