People

Kevin Hong Chen

Kevin Hong Chen

kchen100@jhmi.edu

Publications

  • Zheng W, Hagino T, Wang H, Cheng HY, Koylass N, Chen KH, Wang H, Mani S, Mondal AK, Twomey EC, Qiu Z., 2025, Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport, Mol Cell., 85(24):4621-4632.e7. doi: 10.1016/j.molcel.2025.11.014. PMCID: PMC12698191  PubMed
  • Chen KH, Hagino T, Qiu Z., 2025, The Proton-Activated Chloride Channel: Molecular Identification, Structure, and Role in Organelle Physiology, Annu Rev Physiol., doi: 10.1146/annurev-physiol-022724-105357. PMID: 41197158  PubMed
  • Cheng HY, Chu J, Limjunyawong N, Chen J, Ye Y, Chen KH, Koylass N, Sun S, Dong X, Qiu Z., 2025, Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages, J Exp Med., 222(11):e20250312. doi: 10.1084/jem.20250312. PMCID: PMC12373265 PubMed
  • Shah K, Totty MS, Bach SV, Valentine MR, Chandra A, Divecha HR, Miller RA, Kwon SH, Ramnauth AD, Tippani M, Tyagi S, Kleinman JE, Collado-Torres L, Han S, Hyde TM, Page SC, Maynard KR, Hicks SC, Martinowich K., 2025, Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain, bioRxiv [Preprint], 2025.07.14.664821. doi: 10.1101/2025.07.14.664821. PMCID: PMC12338615  PubMed
  • Koylass N, Sachithanandham J, Osei-Owusu J, Chen KH, Cheng HY, Pekosz A, Qiu Z., 2025, The Proton-Activated Chloride Channel Inhibits SARS-CoV-2 Spike Protein-Mediated Viral Entry Through the Endosomal Pathway, J Cell Physiol., 240(7):e70063. doi: 10.1002/jcp.70063. PMID: 40696792  PubMed
  • 2025 Young Investigators Day: The Michael Shanoff Research
  • Cheng HY, Chu J, Limjunyawong N, Chen J, Ye Y, Chen KH, Koylass N, Sun S, Dong X, Qiu Z., 2025, The phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages, bioRxiv [Preprint], 2025.02.27.640612. doi: 10.1101/2025.02.27.640612. PMCID: PMC11888413  PubMed
  • Chen KH, Yang J, Liu B, Jiang C, Koylass N, Zhang Z, Sun S, Huganir R, Qiu Z., 2025, Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification, Cell Rep., 44(2):115302. doi: 10.1016/j.celrep.2025.115302. PMID: 39946237  PubMed
  • Chen J, Yang J, Chu J, Chen KH, Alt J, Rais R, Qiu Z., 2024, The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity, Adv Sci (Weinh), 11(36):e2401085. doi: 10.1002/advs.202401085. PMCID: PMC11423184  PubMed
  • Liu Y, Fan M, Yang J, Mihaljević L, Chen KH, Ye Y, Sun S, Qiu Z., 2024, KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3, Sci Adv., 10(20):eadm9326. doi: 10.1126/sciadv.adm9326. PMCID: PMC11100567  PubMed
  • Chen K, Ibañez Bruron MC, Mondaca S, Pizarro G, Liberman P, Berkenstock MK., 2023, Quantitative Ocular Surface Changes in Patients Undergoing Immune Checkpoint Inhibitor Therapy, Ocul Immunol Inflamm., 1-4. doi: 10.1080/09273948.2023.2252892. PMID: 37722802  PubMed
  • Yang J, Chen J, Liu Y, Chen KH, Baraban JM, Qiu Z., 2023, Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA, Neuron., 111(7):1104-1117.e6. doi: 10.1016/j.neuron.2022.12.033. PMCID: PMC10079641  PubMed
  • Chu J, Yang J, Zhou Y, Chen J, Chen KH, Zhang C, Cheng HY, Koylass N, Liu JO, Guan Y, Qiu Z., 2023, ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain, Sci Adv., 9(13):eade9931. doi: 10.1126/sciadv.ade9931. PMCID: PMC10058245  PubMed
  • Osei-Owusu J, Ruan Z, Mihaljević L, Matasic DS, Chen KH, Lü W, Qiu Z,2022, Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC, Elife., 11:e82955. doi: 10.7554/eLife.82955. PMCID: PMC9779784  PubMed
  • Chen KH, Qiu Z., 2022, Sensational astrocytes: Mechanotransduction in adult brain function, Neuron., 110(18):2891-2893. doi: 10.1016/j.neuron.2022.08.007. PMID: 36137517  PubMed
  • Osei-Owusu J, Kots E, Ruan Z, Mihaljević L, Chen KH, Tamhaney A, Ye X, Lü W, Weinstein H, Qiu Z., 2022, Molecular determinants of pH sensing in the proton-activated chloride channel, Proc Natl Acad Sci U S A, 2022 Aug 2;119(31):e2200727119. doi: 10.1073/pnas.2200727119. PMCID: PMC9351481  PubMed

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