We study how cells build the human body. We use human pluripotent stem cells to build organoids that recapitulate essential features of developmental processes. With these simplified in vitro models, we dive deep into mechanisms that integrate gene regulation, cellular dynamics, and tissue-level cues to precisely pattern the body plan. We in turn leverage on this knowledge to advance tissue and organ engineering.

Currently we focus on somites and limb buds in the early embryo that respectively give rise to our spine and limbs. We combine live imaging, functional genomics, and biological engineering to uncover fundamental principles of multicellular patterning and morphogenesis. We aim to advance human developmental biology, understand congenital diseases, and promote regenerative medicine.