Image of Rachael Workman Sparklin

Rachael Sparklin


Harold M. Weintraub Graduate Student Award, February 2023


BS, West Virginia State University MS, Portland State University

Modell Lab

2024

Associated BCMB Faculty Member(s)

Name Lab Website
Joshua Modell Lab website

Publications

  • Stoltzfus MJ, Workman RE, Keith NC, Modell JW., 2024, A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage, Nat Microbiol., 9(9):2410-2421. doi: 10.1038/s41564-024-01748-0. PMID: 38997519  PubMed
  • Workman RE, Stoltzfus MJ, Keith NC, Euler CW, Bondy-Denomy J, Modell JW., 2024, Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense, Cell Rep., 43(3):113849. doi: 10.1016/j.celrep.2024.113849. PMID: 38427560  PubMed
  • Workman, RE., Pammi, T., Nguyen, BTK., Graeff, LW., Smith, E., Sebald, SM., Stoltzfus, MJ., Euler, CW., Modell, JW., 2021, A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression, Cell, 184(3):675-688.e19. doi: 10.1016/j.cell.2020.12.017. PMID: 33421369  PubMed

Awards and Distinctions

  • Young Investigators Day Awardees: The Michael A. Shanoff Research Award
  • 2023 Harold M. Weintraub Graduate Student Award
  • 2021 NIH F31 Predoctoral Fellowship
  • 2019 Kelly Scholar