People

image of Huang Paul

Zhiyuan (Paul) Huang

zhuang36@jhu.edu

Publications

Huang Z (UBQLN2 links proteotoxicity…)

Liu Y, Huang Z, Hsu YW, Deme P, Frankenfield AM, Wu S, Zhao X, Liu H, Zhang T, Alexander EJ, Liu M, Zhang Y, Wang H, Zhou Y, Monteiro MJ, Hao L, Haughey NJ, Wang J., 2026, UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration, Nat Neurosci., 29(4):782-795. doi: 10.1038/s41593-026-02226-y. PMCID: PMC13058728  PubMed

Huang Z (C9orf72 hexanucleotide…)

Liu H, Liu M, Liu Y, Gui G, Paul T, Lu YN, Huang Z, Wang H, Xiao Y, Zheng Z, Periz G, Shi Y, Ichida JK, Myong S, Ji H, Wang J., 2026, C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes, Neuron, S0896-6273(25)00932-8. doi: 10.1016/j.neuron.2025.12.005. PMID: 41643661  PubMed

Huang Z (Single-protein/RNA imaging…)

De La Cruz AC, Tisdale G, Nakayama E, Huang Z, Sinha NK, Green R, Wu B., 2025, Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes, EMBO J., 44(18):5215-5232, doi: 10.1038/s44318-025-00523-z. PMCID: PMC12436648  PubMed

He S, Huang Z (DNA break induces…)

He S, Huang Z, Liu Y, Ha T, Wu B., 2024, DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal, Cell Rep., 43(7):114420. doi: 10.1016/j.celrep.2024.114420. PMCID: PMC11337244  PubMed

Huang Z (Protocol to identify DNA-binding…)

Huang Z, Zhou Y, Liu Y, Wang J., 2024, Protocol to identify DNA-binding proteins recognizing nucleotide repeat dsDNAs, STAR Protoc., 5(2):103013. doi: 10.1016/j.xpro.2024.103013. PMCID: PMC11021352  PubMed

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