Protein function is dynamically regulated in the cell by reversible posttranslational modifications. We are interested in the mechanism by which chromatin modifications regulate transcription, nucleosome dynamics and the response to DNA damage. A particular focus is on the non-degradative...
My research interest is to understand the molecular mechanisms of signaling pathways with the goal of understanding what factors regulate the activity of these pathways. This knowledge provides the framework needed to interpret how alterations to a pathway, such...
Research topics: Cryo-electron microscopy, membrane proteins, glutamate receptors, protein homeostasis We are interested in the structural and biochemical underpinnings of neurotransmission and neurodegeneration, as well as the homeostasis of the proteins contributing to these processes. Primarily, we will be...
Research in my laboratory focuses on the molecular basis of the processes that relate to protein nucleic acid interaction. The strategy that we use is based primarily on structural studies using X-ray crystallography, for which I have extensive training....