Albert Lau

Research in my laboratory is focused on understanding the molecular mechanisms of multi-subunit assemblies involved in synaptic communication. We are particularly interested in elucidating the structural thermodynamics that govern subunit assembly, ligand binding, and allosteric control of neurotransmitter receptors....

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Jun Liu

Our primary research interest lies at the interface between chemistry, biology and medicine. We seek to discover new chemical ligands to modulate signaling pathways and cellular processes of interest by conducting high-throughput screening of chemical libraries we generate or...

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Andrew Feinberg

Understanding how the information in the genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself...

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Dominique Frueh

Non-ribosomal peptide synthetases (NRPSs) are large enzymatic systems responsible for the biosynthesis of a wealth of secondary metabolites, many of which are used by pharmaceutical scientists to produce drugs such as antibiotics or anticancer agents. To synthesize all of...

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James C. Barrow

The research group is a laboratory focused on medicinal chemistry, primarilyaddressing diseases of neurodevelopment such as schizophrenia. Biological activity and structure-based drug design are used to drive chemistry target selection, and we are developing synthetic methods to efficiently prepare...

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James M. Berger

Research Interests: My laboratory’s research is focused on understanding how multi-subunit assemblies use ATP for overcoming topological challenges within the chromosome and controlling the flow of genetic information. We are particularly interested in developing mechanistic models that explain how...

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Valina Dawson

My laboratory is actively engaged in discovering and defining cell signaling pathways that lead to either neuronal survival or neuronal death. We have characterized neuronal injury and survival pathways in fly, mouse and human models of Parkinson’s disease and...

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Theresa A. Shapiro

The central theme of our research is chemotherapy of malaria and African sleeping sickness. On a molecular basis, we are interested in understanding the mechanism of action for existing agents, and in identifying vulnerable targets for much-needed new chemotherapy....

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Caren L. Freel-Meyers

We take chemical-biology approaches to pursue new anti-infective strategies. Since 2005, my group has developed approaches to block the indispensable MEP pathway for isoprenoid biosynthesis and vitamin biosynthesis in pathogens. DXP synthase has emerged from this work as a...

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