Peter Espenshade

Regulation of Sterol Homeostasis Elevated serum cholesterol is a primary risk factor for heart disease. A negative feedback mechanism prevents excessive cellular cholesterol accumulation by regulating SREBP, a membrane-bound transcription factor that activates genes required for cholesterol biosynthesis and...

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Andrew Feinberg

Understanding how the information in the genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself...

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Loyal Goff

The goal of my research program is to answer a fundamental biological question: how is the genome properly interpreted to coordinate the diversity of cell types observed during neuronal development? We are focused on the acquisition of specific cellular...

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William Guggino

Endoplasmic Reticulum (ER) is the largest intracellular Ca 2+ store. On the membrane of the ER, there are calcium release components such as inositol 1, 4, 5 trisphosphate receptor (IP 3 R), and the calcium pumps like SR/ER Ca...

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Richard Huganir

Neurotransmitter receptors mediate signal transduction at the postsynaptic membrane of synaptic connections between neurons in the nervous system. We have been studying the molecular mechanisms in the regulation of neurotransmitter receptor function. Recently we have focused on glutamate receptors,...

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Natasha Zachara

The overarching goal of our laboratory is to characterize a novel endogenous protective signaling network of mammalian cells and tissues, in order to provide insight into the molecular mechanisms underlying disease and to highlight novel therapeutic avenues. Cells and...

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Heng Zhu

Fueled by the fast-growing DNA sequence information, proteomics-the large-scale analysis of proteins-has become one of the most important disciplines to characterize protein activities and provide insight into functional network between protein molecules in a high-throughput format. More and more...

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Seth Blackshaw

The vertebrate central nervous system (CNS) is an amazingly complex structure composed of distinct subtypes of neurons and glia. Our lab aims to identify the molecular mechanisms that control the generation of the major cell types of the vertebrate...

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Solange Brown

Our research takes a bottom-up approach to understanding how the neural circuits of this massively interconnected network of neurons are functionally organized and how dysfunction in these circuits contributes to neurodegenerative diseases like amyotrophic lateral sclerosis and neuropsychiatric disorders...

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