Karen Reddy

Understanding the cell biology of genomes and how nuclear architecture controls gene expression is necessary to truly understand biological processes such as development and disease. Although sequencing of the genome and comparative genome analysis have yielded insights into the...

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Hiromi Sesaki

Our laboratory is interested in the molecular mechanisms and physiological roles of mitochondrial fusion. Mitochondria are highly dynamic and control their morphology by a balance of fusion and fission. The regulation of membrane fusion and fission generates a striking...

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Sean Taverna

Eukaryotic cells package their genomes in the form of chromatin, which is comprised of histone proteins and DNA. Modification of chromatin by chemical marks such as methylation and acetylation affects how cellular machineries interpret the genome. The Taverna laboratory...

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Sarah Wheelan

Molecular genetics is built on the assumption that DNA sequence alone is sufficient to direct a cell’s creation, operation, and fate. While this assumption must be modified to accommodate epigenetic phenomena, it is at least clear that the information...

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Patrick Cahan

My lab is an interdisciplinary group that devises and experimentally tests computational tools to explore cell type identity and its molecular underpinnings. A unifying component of our research is the gene regulatory network (GRN). GRNs are programs encoded in...

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Deborah Andrew

We study how epithelial tubular organs – which are essential to life in all multicellular organisms – form and specialize. Using the simple unbranched tubes of the Drosophila salivary gland and the beautifully branched tubular network of the Drosophila...

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Mollie K. Meffert

The goal of the Meffert lab is to gain a mechanistic understanding of how selective gene programs are recruited and maintained to modify the nervous system during development, experience-dependent plasticity, and in injury or disease.  Rather than focusing on...

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Winston Timp

My lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Our research integrates the principles of biophysics, molecular biology,...

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Anthony K. L. Leung

Laboratory of ADP-ribosylation in RNA Biology Our research program focuses on how gene regulation impacts diseases states, including cancer, neurodegeneration and virus infection. Recent research focus includes a druggable protein modification called poly(ADP-ribose). Poly(ADP-ribose) polymerase (PARP) inhibitors are currently...

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