Albert Lau

Research in my laboratory is focused on understanding the molecular mechanisms of multi-subunit assemblies involved in synaptic communication. We are particularly interested in elucidating the structural thermodynamics that govern subunit assembly, ligand binding, and allosteric control of neurotransmitter receptors....

Read More

Dominique Frueh

Non-ribosomal peptide synthetases (NRPSs) are large enzymatic systems responsible for the biosynthesis of a wealth of secondary metabolites, many of which are used by pharmaceutical scientists to produce drugs such as antibiotics or anticancer agents. To synthesize all of...

Read More

Taekjip Ha

My research is focused on pushing the limits of single-molecule detection methods to study complex biological systems. His group develops state-of-the-art biophysical techniques (e.g., multicolor fluorescence, super-resolution imaging, combined force and fluorescence spectroscopy, vesicular encapsulation, single-molecule pull-down) and applies...

Read More

Jie Xiao

My laboratory focuses on developing novel single-molecule imaging tools in live cells to probe various dynamic aspects of cellular processes. We develop single-molecule gene expression reporting systems and chromosomal DNA conformation markers to probe the dynamics of gene regulation...

Read More

James M. Berger

Research Interests: My laboratory’s research is focused on understanding how multi-subunit assemblies use ATP for overcoming topological challenges within the chromosome and controlling the flow of genetic information. We are particularly interested in developing mechanistic models that explain how...

Read More

Jungsan (Jay) Sohn

Research Interests: We are interested in understanding mechanisms that allow biological stress-sensors to detect danger signals and initiate highly coordinated coping-responses by assembling into higher order molecular assemblies. Innate immunity is the first line of defense against invading pathogens...

Read More

Cynthia Wolberger

Protein function is dynamically regulated in the cell by reversible posttranslational modifications. We are interested in the mechanism by which chromatin modifications regulate transcription, nucleosome dynamics and the response to DNA damage. A particular focus is on the non-degradative...

Read More

L. Mario Amzel

Structural Enzymology. Enzymes play a key role in all metabolic and cell-signaling processes. Characterization of an enzyme’s biological function must include the description of its mechanisms at an atomic level. Our laboratory is deciphering the catalytic mechanism of several...

Read More

Edward Twomey

Research topics: Cryo-electron microscopy, membrane proteins, glutamate receptors, protein homeostasis We are interested in the structural and biochemical underpinnings of neurotransmission and neurodegeneration, as well as the homeostasis of the proteins contributing to these processes. Primarily, we will be...

Read More

Bin Wu

Seeing is belief: my lab is interested in visualizing and quantifying biological events as they happen in situ at real time. We use single molecule imaging and spectroscopy technology in live cells, combined with theoretical modeling to extract dynamic...

Read More