Carolyn Machamer

We are interested in the structure and function of the Golgi complex, a ubiquitous eukaryotic organelle that plays a central role in post-translational processing and sorting of newly synthesized proteins and lipids in the secretory pathway. The Golgi complex...

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Rong Li

The goal of our research is to understand how eukaryotic cells polarize, divide, move, and vary their genomes to adapt to the changing environment. We strive for integrated analyses on the systems level that combines whole-cell quantitative observation and...

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Peter Espenshade

Our laboratory’s research focuses on understanding (1) how cells measure levels of available nutrients and (2) how cells adapt to changes in nutrient supply to control metabolic homeostasis. Our studies have primarily centered on changes in cholesterol and oxygen...

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Andrew Ewald

Background and Summary:Epithelial cells in a tissue live a crowded life connected to, and interacting with, other cell types, the extracellular matrix, and diverse signaling molecules. A fundamental question in biology is: how do the constituent cells of an...

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Miho Iijima

Mechanisms of gradient sensing and chemotaxis are conserved in mammalian leukocytes and Dictyostelium amoebae. Both cells use G protein linked signaling pathways. PH domains specific for PtdIns(3,4)P2 and PtdIns(3,4,5)P3 bind to the membrane at the leading edge of the...

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Takanari Inoue

Research Focus  Our research focuses on “synthetic cell biology” to dissect and reconstitute intricate signaling networks. In particular, we investigate positive-feedback mechanisms underlying the initiation of neutrophil chemotaxis (known as a symmetry breaking process), as well as spatio-temporally dynamic...

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Peter Devreotes

Chemotaxis plays a key role in immune response, wound healing, angiogenesis, and embryogenesis as well as mediating cancer metastasis. Research in Dictyostelium discoideum has shown that chemoattractants are sensed by GPCRs and rapidly trigger a complex network of signaling...

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Douglas Robinson

Multi-cellular living organisms grow from single cells into multicellular, complex systems composed of highly diverse cell-types organized into tissues, which in turn form organs and organ systems. To organize and maintain this complex architecture, the organism must undergo constant...

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Hiromi Sesaki

Our laboratory is interested in the molecular mechanisms and physiological roles of mitochondrial fusion. Mitochondria are highly dynamic and control their morphology by a balance of fusion and fission. The regulation of membrane fusion and fission generates a striking...

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Image of Shigeki Watanabe

Shigeki Watanabe

My lab studies the cellular and molecular basis of synaptic transmission and plasticity. Neuronal signaling events at synapses determine circuit responses and result in specific behavioral outputs. This signaling is dynamic – modulated by synapse activity history and perceived...

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