Understanding the cell biology of genomes and how nuclear architecture controls gene expression is necessary to truly understand biological processes such as development and disease. Although sequencing of the genome and comparative genome analysis have yielded insights into the...
Protein function is dynamically regulated in the cell by reversible posttranslational modifications. We are interested in the mechanism by which chromatin modifications regulate transcription, nucleosome dynamics and the response to DNA damage. A particular focus is on the non-degradative...
What are cellular and molecular mechanisms that control tissue regeneration in vivo? Stem cells ensure tissue renewal in most adult tissues, and their activities are under the precise control of signals from specific local microenvironments, or niches. The ability...
Our research seeks to map and engineer cell fate using synthetic biology and genomics approaches. To accomplish this objective, we develop: (A) molecular technologies that write cellular histories into their genomes, (B) sequencing strategies that read out written information...
My lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Our research integrates the principles of biophysics, molecular biology,...
