CRISPR-Cas loci serve as acquired immune systems which protect their bacterial and archaeal hosts from viruses and plasmids. CRISPR immunity occurs in two phases: First, short DNA segments from foreign invaders are captured and inserted into the CRISPR locus...
Our research seeks to map and engineer cell fate using synthetic biology and genomics approaches. To accomplish this objective, we develop: (A) molecular technologies that write cellular histories into their genomes, (B) sequencing strategies that read out written information...