Albert Lau

Research in my laboratory is focused on understanding the molecular mechanisms of multi-subunit assemblies involved in synaptic communication. We are particularly interested in elucidating the structural thermodynamics that govern subunit assembly, ligand binding, and allosteric control of neurotransmitter receptors....

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Rong Li

The goal of our research is to understand how eukaryotic cells polarize, divide, move, and vary their genomes to adapt to the changing environment. We strive for integrated analyses on the systems level that combines whole-cell quantitative observation and...

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Jun Liu

Our primary research interest lies at the interface between chemistry, biology and medicine. We seek to discover new chemical ligands to modulate signaling pathways and cellular processes of interest by conducting high-throughput screening of chemical libraries we generate or...

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Svetlana Lutsenko

Copper plays an essential role in human physiology. It serves as a cofactor to key metabolic enzymes that are required for respiration, neurotransmitter biosynthesis, detoxification of radicals, blood clotting, connective tissue formation, and many others processes. Through currently unknown...

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Carolyn Machamer

We are interested in the structure and function of the Golgi complex, a ubiquitous eukaryotic organelle that plays a central role in post-translational processing and sorting of newly synthesized proteins and lipids in the secretory pathway. The Golgi complex...

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Andrew Feinberg

Understanding how the information in the genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself...

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Dominique Frueh

Non-ribosomal peptide synthetases (NRPSs) are large enzymatic systems responsible for the biosynthesis of a wealth of secondary metabolites, many of which are used by pharmaceutical scientists to produce drugs such as antibiotics or anticancer agents. To synthesize all of...

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Dax Fu

Zinc transporters regulate subcellular zinc distributions to ensure proper metalation of a wide range of cellular proteins that amount to about a third of a mammalian proteome. For example, a human zinc transporter (ZnT8) enriches zinc in the insulin-containing...

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Ryuya Fukunaga

The Fukunaga lab is broadly interested in RNA biology. More specifically, the Fukunaga lab investigates the mechanism and biology of post-transcriptional gene regulation controlled by small silencing RNAs and RNA-binding proteins. Our research projects will answer fundamental biological questions...

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Loyal Goff

The goal of my research program is to answer a fundamental biological question: how is the genome properly interpreted to coordinate the diversity of cell types observed during neuronal development? We are focused on the acquisition of specific cellular...

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