The Peters lab applies a translational medicine approach to study the pathobiology of inflammatory bowel disease (IBD), with the ultimate goal of developing mechanistically novel IBD therapeutics. Our laboratory uses preclinical rodent colitis models and genetically modified mice to...
Using nucleic acid chemistry and biology to create safer cancer drugs and tunable imaging agents for cancer detection. Traditionally antibodies have been considered the gold standard of targeting ligands, able to specifically target desired cellular targets with high affinity....
The evolution of multicellularity occurred hand in hand with the diversification of cell types with disparate morphologies and functions. This segregation of function across different cell types enabled astounding animal complexity; but at the same time, extreme specializations of...
In the Kebschull Lab, we ask how brain areas, circuits, and cell types change across evolution to produce the complex network architecture of extant vertebrate brains. Answering these questions will not only teach us about evolution but reveal general...
The Williams Lab seeks to identify the fundamental mechanisms by which HIV, drugs of abuse, and the antiretroviral therapies used to treat the virus synergize to promote damage to the body. One of the major challenges in HIV eradication...
Redox regulation plays a central role in signal transduction processes operating in the brain. Aberrant redox signaling is a hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis and various Ataxias. It...
Copper plays an essential role in human physiology. It serves as a cofactor to key metabolic enzymes that are required for respiration, neurotransmitter biosynthesis, detoxification of radicals, blood clotting, connective tissue formation, and many others processes. Through currently unknown...
Research in my laboratory is focused on understanding the molecular mechanisms of multi-subunit assemblies involved in synaptic communication. We are particularly interested in elucidating the structural thermodynamics that govern subunit assembly, ligand binding, and allosteric control of neurotransmitter receptors....