My lab focuses on understanding and exploiting the complex signaling properties of human membrane proteins with a particular focus on G-protein coupled receptors (GPCRs). GPCRs adopt a very broad set of distinct conformations, the populations and dynamics of which...
The Cai lab focuses on understanding how the transcription process is regulated in normal and cancer cells. We are intrigued by the discoveries in our lab that many transcription factors involved in cancers can form small, liquid-like condensates in...
My laboratory focuses on developing novel single-molecule imaging tools in live cells to probe various dynamic aspects of cellular processes. We develop single-molecule gene expression reporting systems and chromosomal DNA conformation markers to probe the dynamics of gene regulation...
The ability to monitor arbitrary molecules in situ in the body as we undergo normal daily routines could empower us to make educated decisions regarding our diet, fitness, medical treatments and overall health status. Our laboratory pursues this vision...
My lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Our research integrates the principles of biophysics, molecular biology,...
