Photo of Luisa Cochella

Luisa Cochella

The evolution of multicellularity occurred hand in hand with the diversification of cell types with disparate morphologies and functions. This segregation of function across different cell types enabled astounding animal complexity; but at the same time, extreme specializations of...

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Andrew Feinberg

Understanding how the information in the genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself...

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Rachel Green

The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Our work focuses on understanding how the ribosome functions at a molecular level and how changes in its activity lead to mRNA quality control...

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Andrew Holland

Molecular mechanisms underlying accurate chromosome segregation Since Flemming introduced the term “mitosis” over 100 years ago, a challenge has been to understand how cells divide and faithfully transmit chromosomes at each cell division. Errors in the distribution of chromosomes...

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Janice Clements

Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections. In particular, the simian immunodeficiency virus (SIV) is used to examine the molecular basis for the pathogenesis of HIV CNS disease. Research projects include...

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Jeffry Corden

Eucaryotic RNA polymerase II is unique among RNA polymerases in containing an unusual repetitive domain at the C-terminus of the largest subunit. This C-terminal domain (CTD) is comprised of tandem repeats of the consensus sequence TyrSerProThrSerProSer. We are using...

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Sarah Wheelan

Molecular genetics is built on the assumption that DNA sequence alone is sufficient to direct a cell’s creation, operation, and fate. While this assumption must be modified to accommodate epigenetic phenomena, it is at least clear that the information...

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Sergi Regot

A fundamental property of living cells is their extraordinary ability to sense and respond to a changing environment. In higher eukaryotes, malfunctioning of signaling networks has many devastating consequences such as cancer, diabetes or autoimmunity. Such consequences arise from...

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Geraldine Seydoux

Our lab studies the earliest stages of embryogenesis to understand how single-celled eggs develop into complex multicellular embryos. We study how RNAs and proteins become localized to pattern the developmental potential of newly fertilized eggs. We have identified a...

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