Andrew Feinberg

Understanding how the information in the genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself...

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Rachel Green

The ribosome is the macromolecular complex that translates the genetic code into functional polypeptides. We are interested in how this ribonucleoprotein (RNA + protein) machine catalyzes and coordinates the complex molecular events of translation. Current work in the Green...

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Andrew Holland

Molecular mechanisms underlying accurate chromosome segregation Since Flemming introduced the term “mitosis” over 100 years ago, a challenge has been to understand how cells divide and faithfully transmit chromosomes at each cell division. Errors in the distribution of chromosomes...

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Janice Clements

Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections. In particular, the simian immunodeficiency virus (SIV) is used to examine the molecular basis for the pathogenesis of HIV CNS disease. Research projects include...

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Jeffry Corden

Eucaryotic RNA polymerase II is unique among RNA polymerases in containing an unusual repetitive domain at the C-terminus of the largest subunit. This C-terminal domain (CTD) is comprised of tandem repeats of the consensus sequence TyrSerProThrSerProSer. We are using...

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Randall Reed

The mammalian olfactory system provides an excellent model to study two of the important questions in molecular neurobiology. The continual replacement of olfactory receptor neurons mimics many aspects of neuronal differentiation and development in the brain. The olfactory system,...

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Sergi Regot

A fundamental property of living cells is their extraordinary ability to sense and respond to a changing environment. In higher eukaryotes, malfunctioning of signaling networks has many devastating consequences such as cancer, diabetes or autoimmunity. Such consequences arise from...

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Geraldine Seydoux

Our lab studies the earliest stages of embryogenesis to understand how single-celled eggs develop into complex multicellular embryos. We study how RNAs and proteins become localized to pattern the developmental potential of newly fertilized eggs. We have identified a...

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Robert Siliciano

For the 34 million people infected with HIV-1, the best current hope for avoiding the fatal consequences of the infection lies in treatment with antiretroviral therapy (ART), which consists of combinations of three drugs that inhibit specific steps in...

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