Fueled by the fast-growing DNA sequence information, proteomics-the large-scale analysis of proteins-has become one of the most important disciplines to characterize protein activities and provide insight into functional network between protein molecules in a high-throughput format. More and more...
The research group is a laboratory focused on medicinal chemistry, primarily addressing diseases of neurodevelopment such as schizophrenia. Biological activity and structure-based drug design are used to drive chemistry target selection, and we are developing synthetic methods to efficiently prepare...
Research Interests: My laboratory’s research is focused on understanding how multi-subunit assemblies use ATP for overcoming topological challenges within the chromosome and controlling the flow of genetic information. We are particularly interested in developing mechanistic models that explain how...
The vertebrate central nervous system (CNS) is an amazingly complex structure composed of distinct subtypes of neurons and glia. Our lab aims to identify the molecular mechanisms that control the generation of the major cell types of the vertebrate...
Our research takes a bottom-up approach to understanding how the neural circuits of this massively interconnected network of neurons are functionally organized and how dysfunction in these circuits contributes to neurodegenerative diseases like amyotrophic lateral sclerosis and neuropsychiatric disorders...
Our laboratory studies the molecular and cellular mechanisms underlying the perception of pain under healthy conditions and in the setting of pathology. Towards this goal, we utilize a wide spectrum of approaches including behavioral analysis, in vivo and in...
Phospholipids are the building blocks of biological membranes. Membranes leverage the amphipathic chemistry of lipids to form bilayers that encapsulate a cell and its multitude of organelles. Such compartmentalization has enabled cells to separate biochemical pathways, establish specialized functions...
Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections. In particular, the simian immunodeficiency virus (SIV) is used to examine the molecular basis for the pathogenesis of HIV CNS disease. Research projects include...
Our research is highly collaborative and focuses on developing, optimizing and applying innovative mass spectrometry strategies to reveal the proteins, their modifications, interactomes and adductomes in modulating or monitoring human health and disease. Ongoing research: Albumin Adductome: Air pollution...
