Peter Espenshade

Our laboratory’s research focuses on understanding (1) how cells measure levels of available nutrients and (2) how cells adapt to changes in nutrient supply to control metabolic homeostasis. Our studies have primarily centered on changes in cholesterol and oxygen...

Read More

Miho Iijima

Mechanisms of gradient sensing and chemotaxis are conserved in mammalian leukocytes and Dictyostelium amoebae. Both cells use G protein linked signaling pathways. PH domains specific for PtdIns(3,4)P2 and PtdIns(3,4,5)P3 bind to the membrane at the leading edge of the...

Read More

Alex Kolodkin

Our research is focused on understanding how neuronal connectivity is established during development.  Our work investigates the function of extrinsic guidance cues and their receptors on axonal guidance, dendritic morphology, and synapse formation and function.  For several years we...

Read More

Michael Caterina

Our laboratory studies the molecular and cellular mechanisms underlying the perception of pain under healthy conditions and in the setting of pathology.  Towards this goal, we utilize a wide spectrum of approaches including behavioral analysis, in vivo and in...

Read More
Photo of Natasha Zachara

Natasha Zachara

The overarching goal of our laboratory is to characterize a novel endogenous protective signaling network of mammalian cells and tissues to provide insight into the molecular mechanisms underlying disease and to highlight novel therapeutic avenues. Cells and tissues respond...

Read More

King-Wai Yau

Our laboratory is interested in the area of sensory transduction: specifically visual and olfactory transductions, which are the processes by which the senses of vision and olfaction are initiated. These two processes have interesting similarities and differences. Vision can...

Read More

Paul Worley

The focus of our research is to identify mechanisms of protein synthesis-dependent neuronal plasticity. The approach uses differential cloning techniques to identify mRNAs that are rapidly induced in neurons by synaptic activity. Classical studies established that rapid, de novo...

Read More

G. William Wong

Our lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are broadly interested in how secreted hormones control various aspects of sugar and fat metabolism. Our current efforts centered on addressing how fat...

Read More
Image of Shigeki Watanabe

Shigeki Watanabe

My lab studies the cellular and molecular basis of synaptic transmission and plasticity. Neuronal signaling events at synapses determine circuit responses and result in specific behavioral outputs. This signaling is dynamic – modulated by synapse activity history and perceived...

Read More

Katherine Wilson

We study the structure and function of the cell nucleus, ‘mothership’ of the human genome. We seek to understand how nuclear envelope (NE) membrane proteins interact with nuclear intermediate filament (‘lamina’) networks and other partners to collectively establish, protect...

Read More