Patrick Cahan

My lab is an interdisciplinary group that devises and experimentally tests computational tools to explore cell type identity and its molecular underpinnings. A unifying component of our research is the gene regulatory network (GRN). GRNs are programs encoded in...

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Deborah Andrew

We study how epithelial tubular organs – which are essential to life in all multicellular organisms – form and specialize. Using the simple unbranched tubes of the Drosophila salivary gland and the beautifully branched tubular network of the Drosophila...

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Seth Margolis

Synapses are specialized cell-cell junctions which connect individual neurons together and are the sites of transmission of information between neurons.While the molecular mechanisms which promote synapse formation have been a subject of intense investigation, little is known about the...

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Reza Kalhor

Our research seeks to better understand continuously dynamic biological processes, such as embryonic development and brain activity, by recording cells’ experiences in their genomes. To accomplish this objective, we develop: (A) molecular technologies that write cellular experiences into their...

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Hyungbae Kwon

Our lab focuses on (1) elucidating cellular mechanisms of synaptogenesis in mouse cortex, (2) developing novel technologies that selectively label and control behaviorally-relevant circuits, and (3) dissecting mechanisms of flexible cognitive action controls into cellular level. The first project...

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Thomas Lloyd

Motor neurons are some of the largest cells in the human body, with axon lengths up to a meter long. This large size of motor neurons and muscle cells makes them particularly vulnerable to disruptions of intracellular trafficking with...

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Jennifer Kavran

My research interest is to understand the molecular mechanisms of signaling pathways with the goal of understanding what factors regulate the activity of these pathways. This knowledge provides the framework needed to interpret how alterations to a pathway, such...

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Brady J. Maher

My lab is focused on understanding fundamental mechanisms involved in brain development and brain function with an emphasis on how dysfunction in these mechanisms can result in neurodevelopmental and psychiatric disorders. By focusing on key developmental genes that are...

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Keri Martinowich

Even among similar cell types, differences in synaptic connectivity and activity patterns render these populations functionally and molecularly distinct. While early cell type-specific investigations obtained molecular profiles on the basis of cell-type markers,   molecular genetic tools now allow researchers...

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